Related Experiment Video

Updated: Jul 16, 2025

Studying Left Ventricular Reverse Remodeling by Aortic Debanding in Rodents
07:26

Studying Left Ventricular Reverse Remodeling by Aortic Debanding in Rodents

Published on: July 14, 2021

5.1K

The potential predictive value of cardiac mechanics for left ventricular reverse remodelling in dilated

Ao Kan1, Qimin Fang1, Shuhao Li1

  • 1Department of Radiology, The Second Affiliated Hospital of Nanchang University, Nanchang, China.

ESC Heart Failure
|September 12, 2023
PubMed

Insights

Left ventricular reverse remodelling (LVRR) in dilated cardiomyopathy (DCM) patients is predicted by baseline cardiac magnetic resonance (CMR) parameters. Left ventricular remodelling index (LVRI) and ratio of global longitudinal peak strain (rGLPS) are independent predictors of LVRR.

Area of Science:

  • Cardiology
  • Medical Imaging
  • Biomedical Engineering

Background:

  • Left ventricular reverse remodelling (LVRR) is a key goal in managing dilated cardiomyopathy (DCM).
  • Cardiac magnetic resonance (CMR) offers comprehensive assessment of cardiac structure and function.
  • Identifying predictors of LVRR can optimize patient outcomes.

Purpose of the Study:

  • To assess baseline CMR parameters for predicting LVRR in DCM patients.
  • To investigate independent variables associated with LVRR.
  • To evaluate the diagnostic performance of CMR-derived parameters.

Main Methods:

  • 98 DCM patients underwent baseline CMR and echocardiography.
  • Feature tracking (FT) analysis measured left ventricular (LV) global strain (nStrain) and indexed strain (rStrain).
  • Multivariate logistic regression and ROC curves identified predictors of LVRR.

Main Results:

  • 36% of DCM patients achieved LVRR at 9-month follow-up.
  • Baseline predictors of LVRR included lower LV volume, mass, LGE extent, LVSVi, and higher LVRI, nStrains, rStrains.
  • LVRI (OR 1.79) and rGLPS (OR 1.88) were independent predictors of LVRR.

Conclusions:

  • Patients achieving LVRR had better baseline LV structure and myocardial deformation.
  • LVRI and rGLPS are independent determinants of LVRR in DCM.
  • CMR parameters provide valuable insights into predicting LVRR and guiding DCM management.
Abstract

Keywords:
Cardiac magnetic resonance feature trackingDilated cardiomyopathyReverse remodellingStrain

More Related Videos

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

10.5K
Evaluation of Left Ventricular Structure and Function using 3D Echocardiography06:34

Evaluation of Left Ventricular Structure and Function using 3D Echocardiography

Published on: October 28, 2020

4.0K

Related Concept Videos

Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
11
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
16
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
15
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
12
Aortic Regurgitation II: Clinical Features and Diagnostic Tests01:22

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
23