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Cardiovascular Risk Factors and Events in Fibromyalgia Patients

Fabiola Atzeni1, Mariateresa Cirillo1, Valeria D'Amico1

  • 1Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.

The Israel Medical Association Journal : IMAJ
|September 12, 2023
PubMed

Insights

Fibromyalgia patients have a higher risk of cardiovascular disease, including hypertension and diabetes, compared to the general population. This suggests a specific risk factor profile contributing to increased cardiovascular burden in fibromyalgia.

Area of Science:

  • Cardiovascular Health
  • Rheumatology
  • Epidemiology

Background:

  • Fibromyalgia is linked to neuroendocrine, inflammatory, and coagulation abnormalities.
  • These features may contribute to cardiovascular disease development.
  • The precise cardiovascular risk profile in fibromyalgia requires further definition.

Purpose of the Study:

  • To compare cardiovascular risk factors and events in female fibromyalgia outpatients versus the general Italian population.

Main Methods:

  • Utilized criteria from the CUORE Project to assess cardiovascular risk factors and events.
  • Included 62 female fibromyalgia patients and 4093 female controls (ages 35-75).

Main Results:

  • Fibromyalgia patients showed significantly higher prevalence of hypertension, diabetes, atrial fibrillation, and transient ischemic attack.
  • Cardiovascular total burden was notably higher in fibromyalgia females.
  • No significant differences were observed in fasting glucose, lipid profiles, BMI, or metabolic syndrome (MetS).
  • Methodological limitations may have underestimated the MetS rate.

Conclusions:

  • Fibromyalgia is associated with a greater cardiovascular burden.
  • This increased burden may be mediated by a distinct set of risk factors specific to fibromyalgia.
Abstract

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