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Updated: Jul 16, 2025

Longitudinal Follow-Up of Urinary Tract Infections and Their Treatment in Mice using Bioluminescence Imaging
Published on: June 14, 2021
Daily fosfomycin versus levofloxacin for complicated urinary tract infections
Nadine Rouphael1, Patricia Winokur2, Michael C Keefer3
1Emory University School of Medicine , Atlanta, Georgia, USA.
Importance:
Concerns over resistance and safety have been identified in the current treatment regimen for complicated urinary tract infections. Fosfomycin is a drug that is routinely used for the treatment of uncomplicated cystitis. This study shows that fosfomycin could be an oral alternative as step-down therapy for the treatment of complicated urinary tract infections, with a clinical cure rate comparable to levofloxacin but a lower microbiological success rate 3 weeks from start of antibiotics.
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