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Serum Sema7A is increased in patients with acute aortic dissection
Xing Lyu1, Xin Liu1, Hui Gong2,3
1Department of Clinical Laboratory Medicine, the Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Expert Review of Molecular Diagnostics
|September 12, 2023
Summary
Serum Sema7A is highly expressed in patients with acute aortic dissection (AAD) and may serve as a valuable biomarker for early diagnosis and differentiation from other chest pain conditions like acute myocardial infarction and pulmonary embolism.
Area of Science:
- Biochemistry
- Cardiovascular Medicine
- Diagnostic Biomarkers
Background:
- Acute aortic dissection (AAD) is a life-threatening condition requiring rapid diagnosis.
- Current diagnostic methods can be invasive or have limitations.
- Identifying reliable biomarkers for AAD is crucial for timely intervention.
Purpose of the Study:
- To investigate serum Semaphorin 7A (Sema7A) levels in patients with AAD.
- To evaluate the diagnostic value of serum Sema7A for AAD.
- To assess Sema7A's potential in differentiating AAD from other acute chest pain conditions.
Main Methods:
- Serum Sema7A and plasma D-dimer levels were measured in patients with AAD, acute myocardial infarction (AMI), pulmonary embolism (PE), and healthy controls.
- Statistical analyses were performed to compare levels and assess diagnostic accuracy using receiver operating characteristic (ROC) curves.
Main Results:
- Serum Sema7A concentrations were significantly elevated in AAD patients compared to controls, AMI, and PE groups.
- Serum Sema7A levels correlated positively with D-dimer and decreased after intervention in AAD patients.
- Sema7A demonstrated a high area under the ROC curve (0.842) for diagnosing AAD.
Conclusions:
- Serum Sema7A is significantly upregulated in acute aortic dissection.
- Sema7A shows promise as a sensitive biomarker for early AAD diagnosis.
- Sema7A may aid in differentiating AAD from other acute chest pain emergencies.
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