Related Experiment Video
Updated: Jul 16, 2025
05:44
Novel Methods for Intranasal Administration Under Inhalation Anesthesia to Evaluate Nose-to-Brain Drug Delivery
Published on: November 14, 2018
20.2K
Intranasal Route: A Nasocerebral Approach against SARS-CoV-2 in NeuroCOVID
Abdul Mannan Baig1, Joachim Gerlach2
1Senior Researcher, Lead Scientist COVID-19 and Long-COVID, St. George's Hospital, 83043 Bad Aibling, Germany.
ACS Chemical Neuroscience
|September 12, 2023
Summary
The nasal cavity is a key site for SARS-CoV-2 (the virus causing COVID-19) and its spread to the brain. Targeting this virus in the nose may prevent neurological issues in COVID-19 and long-COVID patients.
Area of Science:
- Virology
- Neuroscience
- Infectious Diseases
Background:
- The nasal cavity harbors significant viral load of SARS-CoV-2.
- Nasal sample collection is standard for COVID-19 diagnosis.
- The cribriform plate facilitates SARS-CoV-2 entry to the olfactory system and brain.
Purpose of the Study:
- To highlight the nasal cavity as a critical site for SARS-CoV-2.
- To emphasize the nasal route's significance in COVID-19 neurological complications.
- To advocate for prioritizing nasal cavity interventions.
Main Methods:
- Review of existing literature on SARS-CoV-2 nasal carriage.
- Analysis of the anatomical connection between the nasal cavity and the brain.
- Evaluation of potential therapeutic strategies targeting the nasal viral load.
Main Results:
- The nasal cavity serves as a primary reservoir for SARS-CoV-2.
- A direct pathway exists from the nasal cavity to the brain via the cribriform plate.
- Neurological deficits in COVID-19 and long-COVID are linked to nasal viral presence.
Conclusions:
- Interventions targeting SARS-CoV-2 within the nasal cavity are crucial.
- Prioritizing the nasal cavity offers a strategy for preventing and treating neurological sequelae.
- The nasal route is a significant consideration for managing COVID-19 and its long-term neurological impact.
Related Concept Videos
01:24Nose and Nasal Cavity
2.8K
The nose is composed of an observable exterior segment (external nose) and an internal segment within the skull known as the nasal cavity (internal nose). The external nose, visible on the face, consists of a framework of bone and hyaline cartilage enveloped in skin and muscle and lined with a mucous membrane. This structure is supported by the frontal bone, nasal bones, and maxillary bone and is supplemented by a cartilaginous framework comprising the septal nasal cartilage, lateral nasal...
2.8K
01:29Suctioning the Nasopharyngeal Airway
495
Nasopharyngeal suctioning is a procedure to remove secretions from the upper part of the respiratory tract that the patient cannot clear independently. It helps maintain airway patency and prevents complications such as aspiration pneumonia.
Equipment Required
Equipment Required
495
01:29Drug Delivery: Parenteral Route
606
The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
606
01:18Additional Routes of Drug Administration
2.8K
Choosing the appropriate route of drug administration is significantly influenced by two key factors: the therapeutic objectives and the inherent properties of the drug being used.
Administering drugs via inhalation allows for the direct delivery of gaseous, volatile substances or droplets to different parts of the respiratory tract. One of the advantages of the inhalation route is the rapid absorption of drugs into the circulatory system, which is possible because of the large surface area of...
Administering drugs via inhalation allows for the direct delivery of gaseous, volatile substances or droplets to different parts of the respiratory tract. One of the advantages of the inhalation route is the rapid absorption of drugs into the circulatory system, which is possible because of the large surface area of...
2.8K