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Novel Methods for Intranasal Administration Under Inhalation Anesthesia to Evaluate Nose-to-Brain Drug Delivery
Published on: November 14, 2018
Intranasal Route: A Nasocerebral Approach against SARS-CoV-2 in NeuroCOVID
Abdul Mannan Baig1, Joachim Gerlach2
1Senior Researcher, Lead Scientist COVID-19 and Long-COVID, St. George's Hospital, 83043 Bad Aibling, Germany.
Abstract:
The nasal cavity is a prime site for viral load of SARS-CoV-2 in COVID-19, as is evident from the fact that this area has been used for sample collection for the diagnosis of COVID-19. The nasal cavity has a connection with the brain across the cribriform plate which has been reported to be a route of SARS-CoV-2 to the olfactory apparatus and the brain. Targeting the SARS-CoV-2 in the nasal cavity in patients presenting with COVID-19 and long-COVID can result in the prevention and treatment of neurological deficits and therefore needs to be prioritized as a route of potential significance.
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