Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Myasthenia Gravis: Diagnostic Tests01:15

Myasthenia Gravis: Diagnostic Tests

978
Myasthenia gravis is an autoimmune condition affecting neuromuscular transmission, causing generalized weakness in skeletal muscles. Initial diagnoses rely on patients' signs, symptoms, and medical history. The challenge lies in distinguishing myasthenia from other muscular dystrophies. An important diagnostic feature is the significant improvement of symptoms after administering anticholinesterase inhibitors.
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...
978
Myasthenia Gravis: Overview and Treatment01:20

Myasthenia Gravis: Overview and Treatment

1.6K
Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
1.6K
Muscle Recovery and Fatigue01:24

Muscle Recovery and Fatigue

2.2K
Muscle fatigue refers to the decline in a muscle's ability to maintain the force of contraction after prolonged activity. It primarily stems from changes within muscle fibers. Even before experiencing muscle fatigue, one may feel tired and have the urge to stop the activity. This response, known as central fatigue, occurs due to changes in the central nervous system, namely the brain and spinal cord. While there is no single mechanism that induces fatigue, it may serve as a protective...
2.2K
Myocarditis II: Clinical Features and Diagnostic Tests01:27

Myocarditis II: Clinical Features and Diagnostic Tests

12
Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
12
Autoimmune Disorders01:29

Autoimmune Disorders

492
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
492
Chronic Obstructive Pulmonary Disease01:22

Chronic Obstructive Pulmonary Disease

1.3K
COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
1.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Influence of CO<sub>2</sub>‑Regenerative Film Properties in Enhancing C<sub>2+</sub> Products Selectivity While Mitigating CO<sub>2</sub> Crossover.

Energy & fuels : an American Chemical Society journal·2026
Same author

Association of rapamycin treatment with the modulation of purine metabolism, reduced microglial inflammatory responses, improved mitochondrial energy metabolism, and alleviation of fatigue symptoms in ME/CFS subjects: pilot findings from phase-II observational study.

Journal of translational medicine·2026
Same author

The Teen-Aged Life Impact Burn Recovery Evaluation profile: Item pool development for a computer adaptive test.

Burns : journal of the International Society for Burn Injuries·2026
Same author

LIBRE GO!: A Mobile Application for Longitudinal Social Participation Assessment and Resources Connection after Burn Injury.

Journal of burn care & research : official publication of the American Burn Association·2026
Same author

Implementing the collaborative chronic care model for mental health: a nonrandomized clinical trial.

Implementation science communications·2026
Same author

Resolving Diagnostic Discordance in Group 2 Pulmonary Hypertension Through Staged Physiologic Testing: Insights From PVDOMICS.

medRxiv : the preprint server for health sciences·2026

Related Experiment Video

Updated: Jul 16, 2025

Induction and Diverse Assessment Indicators of Experimental Autoimmune Encephalomyelitis
06:19

Induction and Diverse Assessment Indicators of Experimental Autoimmune Encephalomyelitis

Published on: September 9, 2022

3.7K

Myalgic Encephalomyelitis-Chronic Fatigue Syndrome Common Data Element item content analysis.

Mary D Slavin1,2, Hannah M Bailey1, Emily J Hickey3

  • 1Department of Health Law Policy and Management, Boston University School of Public Health, Boston, Massachusetts, United States of America.

Plos One
|September 12, 2023
PubMed
Summary

This study reviewed Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Common Data Elements (CDEs), finding most concepts related to body functions like fatigue and sleep. Few items assessed impact on activities, suggesting a need for ME/CFS-specific patient-reported outcome measures.

More Related Videos

Author Spotlight: Unveiling the Pathway Linking Obesity to Autoimmune Inflammation in Multiple Sclerosis
08:17

Author Spotlight: Unveiling the Pathway Linking Obesity to Autoimmune Inflammation in Multiple Sclerosis

Published on: February 23, 2024

4.3K
Flow Cytometric Analysis of Lymphocyte Infiltration in Central Nervous System during Experimental Autoimmune Encephalomyelitis
09:01

Flow Cytometric Analysis of Lymphocyte Infiltration in Central Nervous System during Experimental Autoimmune Encephalomyelitis

Published on: November 17, 2020

7.2K

Related Experiment Videos

Last Updated: Jul 16, 2025

Induction and Diverse Assessment Indicators of Experimental Autoimmune Encephalomyelitis
06:19

Induction and Diverse Assessment Indicators of Experimental Autoimmune Encephalomyelitis

Published on: September 9, 2022

3.7K
Author Spotlight: Unveiling the Pathway Linking Obesity to Autoimmune Inflammation in Multiple Sclerosis
08:17

Author Spotlight: Unveiling the Pathway Linking Obesity to Autoimmune Inflammation in Multiple Sclerosis

Published on: February 23, 2024

4.3K
Flow Cytometric Analysis of Lymphocyte Infiltration in Central Nervous System during Experimental Autoimmune Encephalomyelitis
09:01

Flow Cytometric Analysis of Lymphocyte Infiltration in Central Nervous System during Experimental Autoimmune Encephalomyelitis

Published on: November 17, 2020

7.2K

Area of Science:

  • Neurology
  • Chronic Illness Research
  • Patient-Reported Outcomes

Background:

  • Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a complex multisystem disease affecting millions, characterized by profound fatigue, post-exertional malaise, and cognitive impairment.
  • Diagnosis is challenging due to fluctuating symptoms, highlighting the need for standardized assessment tools.
  • Common Data Elements (CDEs) are crucial for consistent data collection in ME/CFS research and clinical practice.

Purpose of the Study:

  • To review and analyze the item content of ME/CFS Common Data Elements (CDEs) available in the NIH NINDS CDE Repository.
  • To evaluate how well existing CDEs align with the International Classification of Functioning, Disability and Health (ICF) framework.
  • To identify gaps in current CDEs, particularly concerning the impact of ME/CFS on daily activities and participation.

Main Methods:

  • A systematic review of ME/CFS CDEs was conducted, applying specific inclusion criteria (symptom assessment, adult focus, PROM suitability, no visual responses).
  • Independent review of CDE item content by team members.
  • Utilized the World Health Organization ICF framework to categorize and link meaningful concepts within the CDEs.

Main Results:

  • Out of 119 reviewed ME/CFS CDEs, 38 met the inclusion criteria, yielding 944 items linked to 1503 ICF concepts.
  • The majority of concepts (73.65%) mapped to ICF Body Functions (b-codes), with 'Fatiguability,' 'Energy Level,' 'Sleep Functions,' 'Emotional Functions,' and 'Pain' being most frequent.
  • Concepts related to Activities and Participation (d-codes) constituted a smaller proportion (25.62%), with limited assessment of environmental factors (e-codes).

Conclusions:

  • Existing ME/CFS CDEs primarily focus on symptom manifestation (body functions) rather than the impact on daily life (activities and participation).
  • There is a clear need for the development of ME/CFS-specific, psychometrically sound patient-reported outcome measures (PROMs).
  • These PROMs should include items assessing activity limitations and participation restrictions to aid in diagnosis and patient care by primary care providers.