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Related Concept Videos

Transcription Factors02:16

Transcription Factors

76.1K
Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
76.1K
General Transcription Factors01:30

General Transcription Factors

5.4K
Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
5.4K
Master Transcription Regulators02:23

Master Transcription Regulators

6.9K
Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
6.9K
Transcription Elongation Factors02:35

Transcription Elongation Factors

10.9K
Transcription elongation is a dynamic process that alters depending upon the sequence heterogeneity of the DNA being transcribed. Hence, it is not surprising that the elongation complex's composition also varies along the way while transcribing a gene.
The transcription elongation is regulated via pausing of RNA polymerase on several occasions during transcription. In bacteria, these halts are necessary because the transcription of DNA into mRNA is coupled to the translation of that mRNA...
10.9K
Eukaryotic Transcription Activators02:42

Eukaryotic Transcription Activators

11.1K
Transcription activators are proteins that promote the transcription of genes from DNA to RNA. In most cases, these proteins contain two separate domains ‒ a domain that binds to DNA and a domain for activating transcription; however, in some cases, a single domain is responsible for both binding and activation of transcription, as seen in the glucocorticoid receptor and MyoD.
The binding domains are capable of recognizing and interacting with regulatory sequences on the DNA. These...
11.1K
Transcription Initiation01:47

Transcription Initiation

16.5K
Initiation is the first step of transcription in eukaryotes. Prokaryotic RNA Polymerase (RNAP) can bind to the template DNA and start transcribing. On the other hand, transcription in eukaryotes requires additional proteins, called transcription factors, to first bind to the promoter region in the DNA template. This binding helps recruit the specific RNAP that can assemble on the DNA and start transcription.
The promoters and enhancers and their accessory proteins allow tight regulation of...
16.5K

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Neighbors who talk: Mitochondria-lysosome crosstalk in homeostasis.

Current opinion in cell biology·2026
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Association between kidney stones and future risk of kidney cancer: A systematic review and meta-analysis.

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Differential contribution of TFE3 isoforms to cell motility and invasion.

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The lysosomal carrier SLC29A3 supports antibacterial signaling, and promotes autophagy by activating TRPML1 in murine dendritic cells.

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Related Experiment Video

Updated: Jul 16, 2025

An Ecdysone Receptor-based Singular Gene Switch for Deliberate Expression of Transgene with Robustness, Reversibility, and Negligible Leakiness
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An Ecdysone Receptor-based Singular Gene Switch for Deliberate Expression of Transgene with Robustness, Reversibility, and Negligible Leakiness

Published on: May 7, 2018

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TFEB.

Pablo S Contreras1, Rosa Puertollano1

  • 1Cell and Developmental Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.

Current Biology : CB
|September 12, 2023
PubMed
Summary

Researchers introduce Transcription Factor EB (TFEB), a key regulator of cellular stress responses. TFEB controls essential processes like lysosome biogenesis and autophagy for cellular adaptation.

Area of Science:

  • Cellular Biology
  • Molecular Biology
  • Stress Response Mechanisms

Background:

  • Cellular stress necessitates adaptive mechanisms for survival.
  • Lysosome biogenesis and autophagy are critical cellular degradation pathways.
  • Transcription factors play pivotal roles in regulating gene expression during stress.

Purpose of the Study:

  • To introduce Transcription Factor EB (TFEB) as a central regulator of cellular stress responses.
  • To elucidate the role of TFEB in coordinating lysosome biogenesis and autophagy.
  • To understand the molecular mechanisms by which TFEB orchestrates cellular adaptation.

Main Methods:

  • Literature review and synthesis of existing research on TFEB.
  • Analysis of molecular pathways involved in TFEB-mediated gene regulation.

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Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis

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Monitoring eIF4F Assembly by Measuring eIF4E-eIF4G Interaction in Live Cells
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Last Updated: Jul 16, 2025

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  • Examination of the interplay between TFEB, lysosome biogenesis, and autophagy.

    • Main Results:

    • Transcription Factor EB (TFEB) is identified as a master regulator of cellular stress adaptation.
    • TFEB activation leads to the upregulation of lysosome biogenesis.
    • TFEB promotes autophagy, enhancing cellular waste removal and recycling during stress.

    Conclusions:

    • TFEB is a crucial transcription factor for managing cellular stress.
    • Upregulation of lysosome biogenesis and autophagy by TFEB are key adaptive mechanisms.
    • Understanding TFEB's role offers insights into cellular resilience and potential therapeutic targets.