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Updated: Jul 16, 2025

A Protocol for Computer-Based Protein Structure and Function Prediction

A Protocol for Computer-Based Protein Structure and Function Prediction

Published on: November 3, 2011

[Application-oriented structure and function study of proteins: a review].

Xu Han^1,2, Qian Li^1,2, Hongli Wei^1,2

¹National Engineering Research Center for Industrial Enzymes, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China.

Sheng Wu Gong Cheng Xue Bao = Chinese Journal of Biotechnology

|September 12, 2023

Summary

This summary is machine-generated.

Understanding protein structure-function is key for advancing protein engineering and synthetic biology. This research platform enables rapid study of industrial proteins, driving innovation in biomanufacturing.

Keywords:

X-ray crystallography catalytic mechanism protein engineering structural determination structure and function

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Last Updated: Jul 16, 2025

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Published on: November 3, 2011

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Application of I TASSER, trRosetta, UCSF Chimera, HADDOCK server, and HEX loria for De Novo and In Silico Design of Proteins

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Area of Science:

Biotechnology and Protein Engineering
Synthetic Biology
Biomanufacturing

Background:

Advancements in synthetic biotechnology require high-performance proteins for engineered enzymes and strains.
Efficient protein production and rapid structure-function analysis are critical for developing new biotechnologies.
Industrial applications necessitate a deep understanding of protein catalytic functions.

Approach:

Established a protein structure-function study platform over the past decade.
Investigated proteins crucial for natural product synthesis (terpene synthases).
Studied enzymes involved in PET plastic degradation and biomass conversion.

Key Points:

The platform facilitates the preparation of large quantities of high-purity target proteins.
Structure-function studies provide a theoretical foundation for protein engineering.
Progress includes work on terpene synthases, PET-degrading enzymes, and biomass-utilizing enzymes.

Conclusions:

Development of protein structure-function research technologies is essential for synthetic biology.
Enhanced understanding and engineering of proteins will accelerate biomanufacturing.
This work supports the development of novel enzymes and biocatalysts for industrial applications.