Digoxin levels in the serum of healthy neonates

The possible existence of a chemical substance with cross-reactivity to digoxin antibodies in the neonatal serum or plasma was investigated in this study. Our data show that in contrast to previous reports, the levels of a "digoxin-like substance" in the serum or plasma of healthy newborns are negligible and probably would not affect the reliability of digoxin radioimmunoassay tests.