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Related Concept Videos

Parkinson's Disease: Treatment01:24

Parkinson's Disease: Treatment

295
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
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Parkinson's Disease: Overview01:15

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Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
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Related Experiment Video

Updated: Jul 16, 2025

Walk with Me Hybrid Virtual/In-Person Walking for Older Adults with Neurodegenerative Disease
07:21

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The STEPWISE study: study protocol for a smartphone-based exercise solution for people with Parkinson's Disease

Sabine Schootemeijer1, Nienke M de Vries1, Eric A Macklin2,3

  • 1DisordersDonders Institute for Brain, Cognition and Behaviour, Department of Neurology, Center of Expertise for Parkinson & Movement Disorders, Radboud University Medical Center, Nijmegen, the Netherlands.

BMC Neurology
|September 12, 2023
PubMed
Summary

A smartphone app (STEPWISE) aims to boost physical activity in Parkinson's disease (PD) patients. This study investigates its effectiveness over one year for improving step count and overall function.

Keywords:
ExerciseParkinson’s diseasePhysical activityRandomized controlled trialSmartphoneStep count

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Area of Science:

  • Neurology
  • Digital Health
  • Exercise Science

Background:

  • Parkinson's disease (PD) patients face challenges adhering to exercise regimens.
  • Sustainable engagement requires motivating, accessible, and scalable interventions.
  • Smartphone applications offer a potential solution for increasing physical activity.

Purpose of the Study:

  • To assess if the STEPWISE smartphone app increases daily step count in people with PD over 52 weeks.
  • To evaluate the intervention's impact on physical fitness, motor function, and non-motor symptoms.
  • To explore a dose-response relationship between physical activity volume and secondary outcomes.

Main Methods:

  • A double-blind, randomized controlled trial involving 452 Dutch individuals with PD (Hoehn & Yahr stages 1-3).
  • Participants with baseline step counts under 7,000/day were randomized into control or intervention groups with varying step increase targets (25-400%).
  • Primary endpoint: change in step count via the STEPWISE app at 52 weeks; secondary endpoints include fitness and motor/non-motor function.

Main Results:

  • The study is evaluating the STEPWISE app's potential to increase physical activity levels in people with PD.
  • Analysis will focus on between-group differences in step count changes and associations with secondary outcomes.
  • Results are pending, but the trial design allows for robust assessment of the intervention's efficacy.

Conclusions:

  • The STEPWISE trial assesses a smartphone-based intervention for increasing physical activity in Parkinson's disease.
  • Motivational apps may enhance adherence to exercise recommendations.
  • This approach could facilitate remote clinical trials for PD exercise interventions.