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Author Spotlight: Unveiling the Polyfunctionality and Heterogeneity in Immune Responses

Author Spotlight: Unveiling the Polyfunctionality and Heterogeneity in Immune Responses

Published on: March 8, 2024

Nanoparticles and cytokine response.

Mohammad Nasrullah¹, Daniel Nisakar Meenakshi Sundaram², Jillian Claerhout¹

¹Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada.

Frontiers in Bioengineering and Biotechnology

|September 13, 2023

Summary

Synthetic nanoparticles (NPs) are promising for gene therapy but can trigger unwanted immune responses. Engineering NPs to control cytokine release is key for safe and effective nucleic acid delivery.

Keywords:

biocompatibility cytokine response inflammatory response nanoparticle non-viral delivery

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Detection of Fluorescent Nanoparticle Interactions with Primary Immune Cell Subpopulations by Flow Cytometry

Detection of Fluorescent Nanoparticle Interactions with Primary Immune Cell Subpopulations by Flow Cytometry

Published on: March 28, 2014

Area of Science:

Biomaterials Science
Immunology
Gene Therapy

Background:

Synthetic nanoparticles (NPs) are explored as non-viral vectors for nucleic acid delivery in gene therapy.
The efficacy and safety of NP-based delivery systems are influenced by NP physicochemical properties and host interactions.
Cytokine responses to NPs are critical for therapeutic outcomes and can lead to unintended consequences.

Purpose of the Study:

To review recent literature on cytokine responses to nanoparticulate delivery systems.
To identify factors influencing NP-induced cytokine responses.
To discuss strategies for engineering NPs with controlled cytokine profiles for improved clinical interventions.

Main Methods:

Literature review of studies on nanoparticle-mediated gene delivery and associated immune responses.
Analysis of physicochemical NP features and administration routes influencing cytokine profiles.
Examination of therapeutic strategies targeting cytokine pathophysiology in disease contexts.

Main Results:

NP physicochemical properties and administration methods significantly impact elicited cytokine responses.
Certain NP features are identified as key triggers of the cytokine response.
Strategies for modulating cytokine responses in diseases involving cytokine dysregulation are presented.

Conclusions:

Controlling nanoparticle-induced cytokine responses is crucial for enhancing the safety and efficacy of gene therapy.
Engineering NP systems with predictable cytokine modulation capabilities holds promise for future clinical applications.
Understanding NP-host interactions is essential for designing next-generation therapeutic delivery systems.