Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

TRPS1 and GATA3 expression in BRG1/SMARCA4-deficient malignant neoplasms.

Human pathology·2026
Same author

Limited predictive value of PD-L1 TPS for pathological response in NSCLC is not attributable to interobserver variability.

Lung cancer (Amsterdam, Netherlands)·2026
Same author

Thymic hyperplasia with lymphoepithelial sialadenitis-like features A single-institution series of 21 new cases.

Human pathology·2026
Same author

Machine Learning Assessment of Pathologic Response in Lung Cancer Resections After Neoadjuvant Therapy-IASLC MPR Project.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer·2026
Same author

Solid, cystic, and mucinous spindle cell thymomas (WHO type A): A clinicopathological and immunohistochemical study of 7 cases.

Human pathology·2026
Same author

From the archives of MD Anderson Cancer Center: Paraneoplastic autoimmune multiorgan syndrome (PAMS) associated with stroma-rich Castleman disease.

Annals of diagnostic pathology·2026

Related Experiment Video

Updated: Jul 16, 2025

Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors
08:57

Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors

Published on: May 17, 2024

2.0K

Spindle cell thymoma and its histological mimickers.

Annikka Weissferdt1

  • 1Department of Anatomic Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Mediastinum (Hong Kong, China)
|September 13, 2023
PubMed
Summary

Spindle cell thymomas are common anterior mediastinum tumors. This review aids diagnosis by differentiating them from other spindle cell neoplasms with similar features.

Keywords:
Mediastinumsarcomaspindle cellthymic carcinoid tumorthymic carcinomathymoma

More Related Videos

Spontaneous Murine Model of Anaplastic Thyroid Cancer
05:39

Spontaneous Murine Model of Anaplastic Thyroid Cancer

Published on: February 3, 2023

1.7K
Tubal Cytology of the Fallopian Tube as a Promising Tool for Ovarian Cancer Early Detection
08:09

Tubal Cytology of the Fallopian Tube as a Promising Tool for Ovarian Cancer Early Detection

Published on: July 25, 2017

12.4K

Related Experiment Videos

Last Updated: Jul 16, 2025

Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors
08:57

Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors

Published on: May 17, 2024

2.0K
Spontaneous Murine Model of Anaplastic Thyroid Cancer
05:39

Spontaneous Murine Model of Anaplastic Thyroid Cancer

Published on: February 3, 2023

1.7K
Tubal Cytology of the Fallopian Tube as a Promising Tool for Ovarian Cancer Early Detection
08:09

Tubal Cytology of the Fallopian Tube as a Promising Tool for Ovarian Cancer Early Detection

Published on: July 25, 2017

12.4K

Area of Science:

  • Pathology
  • Oncology
  • Thoracic Surgery

Background:

  • Spindle cell thymomas are the most frequent spindle cell neoplasms in the anterior mediastinum.
  • These thymic epithelial neoplasms exhibit significant histomorphologic diversity, complicating diagnosis, especially from small biopsies.
  • Unconventional tumor patterns and differential diagnoses involving other mediastinal spindle cell neoplasms present diagnostic challenges.

Purpose of the Study:

  • To provide a comprehensive review of spindle cell thymoma.
  • To focus on the differential diagnosis of spindle cell thymoma with other anterior mediastinal spindle cell neoplasms.
  • To offer insights into the clinical, pathological, immunohistochemical, and molecular features of these lesions.

Main Methods:

  • Review of literature on spindle cell thymomas and related mediastinal neoplasms.
  • Analysis of clinical, pathological, immunohistochemical, and molecular data.
  • Comparison of diagnostic features to distinguish spindle cell thymoma from other entities.

Main Results:

  • Spindle cell thymoma diagnosis is challenging due to histological heterogeneity and overlapping features with other neoplasms.
  • Differential diagnosis includes thymic epithelial tumors (sarcomatoid carcinoma, carcinoid tumor), mesenchymal neoplasms (SFT, synovial sarcoma, dedifferentiated liposarcoma), and others.
  • Key diagnostic hallmarks (clinical, pathological, immunohistochemical, molecular) are crucial for accurate differentiation.

Conclusions:

  • Accurate diagnosis of spindle cell thymoma requires careful consideration of its varied morphology and comparison with other mediastinal spindle cell neoplasms.
  • Understanding the distinct features of thymic epithelial tumors, mesenchymal neoplasms, and other spindle cell lesions is essential.
  • This review provides practical guidance for pathologists and clinicians managing these complex cases.