[Theophylline concentration in the blood of children with persistently recurring bronchial asthma]
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Theophylline effectively reduces asthma recurrence in children when doses are individualized. Combining it with other asthma medications enhances its effect without altering drug metabolism.
Area of Science:
- Pediatric Pulmonology
- Pharmacology
- Asthma Management
Background:
- Severe bronchial asthma significantly impacts children's quality of life.
- Recurrence of asthma symptoms necessitates effective long-term management strategies.
Purpose of the Study:
- To evaluate the antirecurrence efficacy and safety of theophylline in children with severe bronchial asthma.
- To determine optimal individualized dosing and administration regimens for theophylline.
- To investigate the impact of combination therapy on theophylline's efficacy and biotransformation.
Main Methods:
- Study included 32 children (3-12 years) with severe bronchial asthma.
- Theophylline dosage was adjusted stepwise (10-30 mg/kg/day) based on clinical and respiratory function parameters.
- Blood theophylline levels were monitored using an immunofluorescent assay.
- Individual drug biotransformation patterns were assessed.
Main Results:
- Theophylline demonstrated a significant antirecurrence effect in pediatric asthma patients.
- Individualized dosing and administration regimens were crucial for efficacy and safety.
- Theophylline was found to be highly effective and safe when doses were tailored to each patient.
- Concurrent use of inhaled beta-adrenomimetics and corticosteroids potentiated theophylline's clinical benefits.
- Combination therapy did not alter theophylline's biotransformation.
Conclusions:
- Individualized theophylline therapy is a highly effective and safe antirecurrence strategy for severe pediatric asthma.
- Combination therapy with inhaled bronchodilators and corticosteroids can enhance theophylline's effectiveness.
- Understanding individual drug biotransformation is key to optimizing theophylline treatment in children.
Abstract:
An antirecurrence effect of theophylline was studied in 32 children aged 3 to 12 years suffering from severe bronchial asthma. The drug dosage was determined by means of a stepwise increase of a daily dose in the range of 10-30 mg/kg/day under control of the patient's general condition and parameters of external respiratory function. Blood theophylline concentration was measured by an immunofluorescent method. The drug individual biotransformation was revealed. Euphylline proved to be a highly effective and safe antirecurrence agent in an individual selection of doses and administration regimens. Combination of theophylline with inhalation beta-adrenomimetics and corticosteroids potentiates its clinical effect without influencing biotransformation.