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Related Experiment Videos

[Cimetidine pharmacokinetics].

S P Katrukha, E V Karpenko, S M Davydov

    Farmakologiia I Toksikologiia
    |September 1, 1986
    PubMed
    Summary

    This study investigated cimetidine pharmacokinetics in patients. Oral cimetidine showed a bioavailability of 36%, with consistent levels during long-term treatment.

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    Area of Science:

    • Pharmacology
    • Clinical Pharmacy

    Background:

    • Cimetidine is a widely used medication.
    • Understanding its pharmacokinetic profile is crucial for effective dosing.

    Purpose of the Study:

    • To determine the pharmacokinetic parameters of cimetidine after intravenous and oral administration.
    • To assess cimetidine bioavailability and its concentration over time during continuous treatment.

    Main Methods:

    • Pharmacokinetic analysis in 9 patients following single intravenous (200 mg) and oral (400 mg) doses.
    • Utilized a two-compartment model for intravenous data analysis.
    • Monitored plasma concentrations over time, noting dual peaks after oral administration.

    Main Results:

    • Key pharmacokinetic parameters derived: t1/2 beta = 1.7 h, t1/2 alpha = 0.12 h, Vd = 1.0 L/kg, Cis = 0.43 L/kg/h, Cior = 1.2 L/kg/h.
    • Oral bioavailability of cimetidine was determined to be 36%.
    • During a course of treatment (1 g/day), pre-dose cimetidine concentrations remained stable on days 6 and 12.

    Conclusions:

    • Cimetidine exhibits specific pharmacokinetic characteristics influencing its absorption and distribution.
    • The calculated bioavailability suggests significant first-pass metabolism or absorption limitations.
    • Consistent trough concentrations during maintenance therapy indicate predictable accumulation or steady-state achievement.

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