[Mechanism of the anti-anginal action of korinfar]

The effect of corinfar on the blood plasma Ca2+ content and oxyhemoglobin dissociation curve was studied in 52 patients with ischemic heart disease. The drug was administered in a dose of 60 mg/day and to 5 patients in a dose of 90 mg/day for 2 weeks. A complete disappearance of angina attacks and ECG normalization were observed in 37 patients, a good effect was noted in 30 patients and no effect was seen in 13 patients. A significant decrease of Ca2+ content during treatment was noted in patients with effort angina of mild and moderate degrees. Parallelism between Ca2+ content decrease and the drug efficacy was revealed.