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Jingmen tick virus: an emerging arbovirus with a global threat
Zhen Wu1, Ming Zhang1, Yuli Zhang1
1WeiFang Medical University , Weifang, Shandong, China.
Abstract:
Jingmen tick virus (JMTV), belonging to the Flaviviridae family, is a novel segmented RNA virus identified in 2014 in the Jingmen region of Hubei Province, China. Up to now, JMTV has been detected in a variety of countries or regions in Asia, Europe, Africa, and the Americas, involving a wide range of arthropods and mammals, and even humans. The JMTV genome is composed of four linear RNA segments, two of which are derived from flaviviruses, while the other two segments are unique to JMTV and has no matching virus. Currently, JMTV has been shown to have a pathogenic effect on humans. Humans who had been infected would develop viremia and variable degrees of clinical symptoms. However, the pathogenic mechanism of JMTV has not been elucidated yet. Therefore, it is crucial to strengthen the epidemiological surveillance and laboratory studies of JMTV.
Insights
Jingmen tick virus (JMTV) is a novel segmented RNA virus found globally. While JMTV causes human illness, its exact disease mechanism remains unknown, necessitating further research and surveillance.
Area of Science:
- Virology
- Infectious Diseases
- Epidemiology
Background:
- Jingmen tick virus (JMTV), a segmented RNA virus from the Flaviviridae family, was first identified in China in 2014.
- JMTV has a global distribution, detected across Asia, Europe, Africa, and the Americas, affecting various arthropods, mammals, and humans.
- The virus possesses a unique four-segment RNA genome, with two segments related to flaviviruses and two unique segments.
Purpose of the Study:
- To highlight the emerging threat of JMTV.
- To emphasize the need for further investigation into JMTV's pathogenic mechanisms.
- To underscore the importance of enhanced epidemiological surveillance and laboratory studies for JMTV.
Main Methods:
- Literature review of existing JMTV data.
- Genomic analysis of JMTV RNA segments.
- Clinical and epidemiological data compilation.
Main Results:
- JMTV has been detected in multiple continents, indicating a wide host range and geographical spread.
- Human infections with JMTV result in viremia and diverse clinical symptoms.
- The specific mechanisms by which JMTV causes disease in humans are currently not well understood.
Conclusions:
- JMTV represents a significant emerging viral pathogen with global reach.
- Understanding JMTV's pathogenesis is critical for developing effective countermeasures.
- Continued epidemiological monitoring and in-depth laboratory research are essential for managing JMTV risks.
