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Buphenine and threatened abortion.
European Journal of Obstetrics, Gynecology, and Reproductive Biology
|September 1, 1986
Summary
Buphenine hydrochloride, a uterine muscle relaxant, significantly improved pregnancy continuation rates in threatened abortion cases. This treatment showed promising results, especially for patients with a history of recurrent pregnancy loss.
Area of Science:
- Obstetrics and Gynecology
- Pharmacology
Background:
- Threatened abortion is a common complication in early pregnancy.
- Identifying effective treatments to improve pregnancy continuation is crucial.
Purpose of the Study:
- To evaluate the efficacy of buphenine hydrochloride in managing threatened abortion.
- To compare pregnancy continuation rates between buphenine hydrochloride and placebo treatment groups.
Main Methods:
- A randomized controlled study involving 170 patients with threatened abortion.
- Group 1 (85 patients) received buphenine hydrochloride.
- Group 2 (85 patients) received a placebo.
Main Results:
- Pregnancy continuation was observed in 90.6% of patients treated with buphenine hydrochloride.
- Pregnancy continuation was observed in 62.3% of patients receiving placebo.
- In patients with a history of recurrent abortion, only 3 out of 22 treated with buphenine hydrochloride experienced abortion.
Conclusions:
- Buphenine hydrochloride demonstrates significant efficacy in improving pregnancy continuation rates for threatened abortions.
- The uterine muscle relaxant appears particularly beneficial for women with recurrent pregnancy loss.