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Updated: Jul 16, 2025
08:10
Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation
Published on: July 20, 2022
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Long Non-coding RNA Involved in the Pathophysiology of Atrial Fibrillation
Zikan Zhong1, Xintao Li2, Longzhe Gao1
1Department of Cardiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Cardiovascular Drugs and Therapy
|September 13, 2023
Summary
Long non-coding RNAs (lncRNAs) are implicated in atrial fibrillation (AF) pathogenesis. Targeting these lncRNAs, particularly their role as miRNA sponges, offers a promising therapeutic strategy for AF management.
Area of Science:
- Cardiovascular Research
- Molecular Biology
- Genetics
Background:
- Atrial fibrillation (AF) involves complex pathophysiological changes, including electrical and structural remodeling, calcium handling issues, autonomic dysfunction, metabolic alterations, and immune dysregulation.
- Long non-coding RNAs (lncRNAs) are increasingly recognized for their significant role in the development and progression of AF.
Purpose of the Study:
- To elucidate the involvement of AF-related lncRNAs in disease pathogenesis.
- To focus on the function of lncRNAs as miRNA sponges modulating key signaling pathways in AF.
- To review current research limitations and explore future therapeutic directions for lncRNA-targeted AF treatment.
Main Methods:
- Literature review and synthesis of current research on lncRNAs in AF.
- Analysis of lncRNA mechanisms, particularly their role as miRNA sponges.
- Evaluation of potential therapeutic strategies and delivery systems for lncRNAs in AF.
Main Results:
- AF-related lncRNAs, functioning as miRNA sponges, significantly influence signaling pathways critical to AF progression.
- Current research faces limitations in fully understanding lncRNA functions and therapeutic applications in AF.
- Feasible strategies and promising delivery systems for targeting lncRNAs in AF therapy are being developed.
Conclusions:
- Targeting AF-related lncRNAs presents a substantial and promising avenue for future research.
- Modulating lncRNA function offers a potential novel therapeutic strategy for managing atrial fibrillation.
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