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Predictive biomarkers for the early detection and management of heart failure

Vignesh Mariappan1, Rajesh Srinivasan1, Ravindran Pratheesh2

  • 1Mahatma Gandhi Medical Advanced Research Institute (MGMARI), Sri Balaji Vidyapeeth (Deemed to be University), Puducherry, 607402, India.

Heart Failure Reviews
|September 13, 2023
PubMed

Insights

Identifying circulating biomarkers is crucial for early detection and management of heart failure (HF), a growing public health concern. This review explores omics platforms and biomarkers, including those related to endothelial biology, for improved HF prediction and personalized treatment strategies.

Area of Science:

  • Biomolecular Science
  • Cardiovascular Research
  • Public Health

Background:

  • Cardiovascular disease (CVD) is a rising global health issue, with heart failure (HF) projected as a leading cause of mortality.
  • HF is a complex syndrome with diverse causes and pathophysiology, involving inflammatory, apoptotic, fibrotic, and neuro-humoral pathways.
  • Circulating biomolecules released during HF progression can indicate subclinical changes and disease severity.

Purpose of the Study:

  • To provide a comprehensive overview of omics platforms for discovering heart failure biomarkers.
  • To discuss existing and novel biomarkers for early HF detection, emphasizing endothelial biology.
  • To highlight the importance of identifying biomarkers for early prediction and personalized HF management.

Main Methods:

  • Review of current omics technologies for biomarker discovery in heart failure.
  • Analysis of literature on established and emerging biomarkers for HF.
  • Focus on biomarkers related to endothelial function and cardiovascular health.

Main Results:

  • Omics platforms offer powerful tools for identifying novel heart failure biomarkers.
  • Several circulating biomolecules show potential for early HF detection and monitoring.
  • Endothelial biology-related markers are significant in understanding HF pathogenesis and progression.

Conclusions:

  • Early identification of circulating biomarkers is essential for predicting and managing heart failure.
  • Multi-biomarker strategies and omics approaches can enable personalized treatment strategies for HF patients.
  • Further research into novel biomarkers, particularly those linked to endothelial function, is critical for advancing HF care.

Keywords:
BiomarkersHeart failureOmicsPrognosismiRNAs

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