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Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid
Published on: September 20, 2017
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Self-assembling peptides for managing white spot lesions: a systematic review and meta-analysis
K Rathore1, A K Patnana2,3, V K Chugh2
1Department of Dentistry, All India Institute of Medical Sciences, Jodhpur, Rajasthan, 342005, India. rathorekanu@gmail.com.
Summary
Self-assembling P11-4 peptide (SAP) with or without fluoride agents shows uncertain effectiveness for remineralizing white spot lesions. More high-quality research is needed to determine its role in treating incipient carious lesions.
Area of Science:
- Biomaterials Science
- Dental Research
- Nanotechnology
Background:
- White spot lesions (WSLs) and incipient carious lesions (ICLs) represent early stages of tooth decay.
- Effective remineralization strategies are crucial for preventing caries progression.
- Self-assembling P11-4 peptide (SAP) has emerged as a potential agent for enamel remineralization.
Approach:
- A systematic review and meta-analysis was conducted on human randomized controlled trials (RCTs) published between January 2000 and June 2021.
- Studies were identified through comprehensive searches of PubMed, Google Scholar, and The Cochrane Central Register of Controlled Trials.
- Risk of bias was assessed using the Cochrane RoB 2 tool, and statistical heterogeneity was evaluated using the Cochrane Q and I² tests. A random-effects model was employed.
Key Points:
- Four of the eight included trials exhibited a high risk of bias, potentially affecting the reliability of the findings.
- Meta-analysis results for SAP versus fluoride agents (FA) showed no significant difference in remineralization using Laser fluorescence (MD = -4.89) or Nyvad criteria (RR = 0.12).
- However, SAP combined with FA demonstrated a significant positive effect on remineralization compared to FA alone, as indicated by Laser fluorescence (MD = -11.52, p < 0.001).
Conclusions:
- The current evidence is insufficient to definitively conclude whether SAP, alone or with FA, effectively remineralizes WSLs/ICLs.
- While SAP + FA showed promise, the high risk of bias in several studies necessitates cautious interpretation.
- Further high-quality RCTs with standardized outcome measures are required to establish the efficacy of SAP-based therapies for enamel remineralization.
