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Apolipoprotein E polymorphism and hyperlipemia in type II diabetics.

M Eto, K Watanabe, Y Iwashima

    Diabetes
    |December 1, 1986
    PubMed
    Summary

    Apolipoprotein E (apoE) gene variations influence hyperlipemia risk in type II diabetes. The apoE3/2 phenotype showed the highest susceptibility to hyperlipemia in both diabetic and non-diabetic individuals.

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    Area of Science:

    • Genetics
    • Metabolic Disorders
    • Cardiovascular Health

    Background:

    • Apolipoprotein E (apoE) plays a crucial role in lipid metabolism.
    • Genetic variations in apoE are associated with differences in plasma lipid levels and cardiovascular disease risk.
    • Type II diabetes mellitus is frequently accompanied by dyslipidemia, increasing cardiovascular risk.

    Purpose of the Study:

    • To investigate the relationship between apolipoprotein E (apoE) polymorphism and plasma lipids in type II diabetics compared to non-diabetics.
    • To determine how different apoE phenotypes influence susceptibility to hyperlipemia.
    • To examine the impact of diabetes on plasma lipid profiles across various apoE phenotypes.

    Main Methods:

    • Investigated 105 male type II diabetics and 111 male non-diabetics.

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  • Determined apoE phenotypes using a rapid flat gel isoelectric focusing method.
  • Analyzed plasma lipid levels, including total cholesterol, LDL cholesterol, HDL cholesterol, triglycerides, and VLDL components.

    • Main Results:

    • Hyperlipemia was more prevalent in diabetics (56.2%) than non-diabetics (32.4%).
    • The apoE3/2 phenotype exhibited the highest susceptibility to hyperlipemia in both groups.
    • Diabetes differentially affected lipid profiles based on apoE phenotype, with specific increases in total and LDL cholesterol in apoE3/2 and apoE4/3 diabetics, and decreased HDL cholesterol in apoE3/3 diabetics.

    Conclusions:

    • Apolipoprotein E polymorphism significantly influences hyperlipemia susceptibility and lipid profiles in type II diabetes.
    • The apoE3/2 phenotype is associated with increased risk of hyperlipemia in diabetic individuals.
    • Diabetes-induced lipid alterations are modulated by apoE genotype, highlighting the importance of personalized risk assessment.