Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Working Memory01:24

Working Memory

246
Working memory refers to a combination of components, including short-term memory and attention, that allow an individual to hold information temporarily as we perform cognitive tasks. It is an essential cognitive function that enables the execution of complex tasks such as problem-solving, comprehension, and reasoning. Unlike short-term memory, which simply involves the storage of information for a brief period, working memory involves the active manipulation and processing of this...
246
Cognitive Development During Adolescence01:18

Cognitive Development During Adolescence

79
During adolescence, individuals experience significant cognitive development that enhances their understanding of others' emotions and thoughts, known as cognitive empathy. This period is marked by an increased ability to adapt to others' perspectives and a more nuanced understanding of others' mental states, a skill that is foundational for social problem-solving and conflict avoidance. The development of cognitive empathy relies heavily on the theory of mind — the...
79
Information Processing Approach01:30

Information Processing Approach

71
The information-processing theory of cognitive development centers on fundamental mental processes, including attention, memory, and problem-solving skills. Researchers in this field examine how cognitive abilities, such as working memory, evolve and influence children's overall development. Studies indicate that children with stronger working memory tend to excel in reading comprehension, math, and problem-solving compared to peers with less efficient memory skills. Low working memory is...
71
Role of Cerebellum and Prefrontal Cortex in Memory01:14

Role of Cerebellum and Prefrontal Cortex in Memory

470
The cerebellum, while traditionally associated with motor control, also plays a crucial role in memory, particularly in procedural memory, which involves learning motor tasks that become automatic through repetition. For example, studies have shown that when the cerebellum is damaged, individuals or animals lose the ability to learn conditioned motor responses, such as the conditioned eye-blink response in classical conditioning experiments with rabbits. This study demonstrates the...
470
Revisionist Views of Adolescent and Adult Cognition01:24

Revisionist Views of Adolescent and Adult Cognition

62
A revisionist approach to Jean Piaget's theory of cognitive development has brought new insights that challenge and reinterpret his established ideas. Piaget proposed that the formal operational stage, emerging in adolescence, represents the culmination of cognitive maturity. During this stage, individuals are said to develop abstract thinking, engage in systematic problem-solving, and show a form of egocentrism, believing others are as preoccupied with their behavior as they are...
62
Attention-Deficit/Hyperactivity Disorder01:30

Attention-Deficit/Hyperactivity Disorder

90
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
90

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multi-modality Graph Representation Learning for Malignant Cell Identification from scRNA-seq using DeepMalignant.

bioRxiv : the preprint server for biology·2026
Same author

Interpretable spatial multi-omics data integration and dimensionality reduction with SpaMV.

Nature communications·2026
Same author

CSsingle: a unified tool for robust decomposition of bulk and spatial transcriptomic data across diverse single-cell references.

Nucleic acids research·2026
Same author

A little longer, a lot better: simulation-guided exploration of extended-length single-end barcoded reads for structural variant detection.

bioRxiv : the preprint server for biology·2026
Same author

scLongTree: an accurate computational tool to infer the longitudinal tree for scDNAseq data.

bioRxiv : the preprint server for biology·2026
Same author

Poxvirus A52 protein subverts autophagy flux by blocking autophagosome-lysosome fusion to promote viral replication.

PLoS pathogens·2026

Related Experiment Video

Updated: Jul 16, 2025

A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance
09:01

A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance

Published on: May 7, 2014

10.2K

Laminar pattern of adolescent development changes in working memory neuronal activity.

Junda Zhu1, Benjamin M Hammond1, Xin Maizie Zhou2,3

  • 1Program in Neuroscience, Vanderbilt University, Nashville, Tennessee, United States.

Journal of Neurophysiology
|September 13, 2023
PubMed
Summary
This summary is machine-generated.

Adolescent brain development shows improved working memory. Neurophysiological changes occur across cortical layers, with significant increases in middle layers, not just superficial ones.

Keywords:
adolescencecerebral cortexlayerprefrontal cortexworking memory

More Related Videos

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity
10:43

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity

Published on: July 1, 2014

15.2K
Immunohistochemical Visualization of Hippocampal Neuron Activity After Spatial Learning in a Mouse Model of Neurodevelopmental Disorders
07:43

Immunohistochemical Visualization of Hippocampal Neuron Activity After Spatial Learning in a Mouse Model of Neurodevelopmental Disorders

Published on: May 12, 2015

11.3K

Related Experiment Videos

Last Updated: Jul 16, 2025

A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance
09:01

A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance

Published on: May 7, 2014

10.2K
Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity
10:43

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity

Published on: July 1, 2014

15.2K
Immunohistochemical Visualization of Hippocampal Neuron Activity After Spatial Learning in a Mouse Model of Neurodevelopmental Disorders
07:43

Immunohistochemical Visualization of Hippocampal Neuron Activity After Spatial Learning in a Mouse Model of Neurodevelopmental Disorders

Published on: May 12, 2015

11.3K

Area of Science:

  • Neuroscience
  • Developmental Neuroscience
  • Cognitive Neuroscience

Background:

  • Adolescence is a critical period for cognitive development, including significant improvements in working memory.
  • Prefrontal cortex undergoes structural changes during adolescence, coinciding with enhanced working memory capacity.
  • Previous research suggested working memory-related neural activity changes were primarily in superficial cortical layers.

Purpose of the Study:

  • To investigate the laminar distribution of neurophysiological changes in the prefrontal cortex during adolescent development.
  • To determine if changes in neural activity associated with working memory maturation are confined to superficial cortical layers.

Main Methods:

  • Analysis of neurophysiological recordings from male monkeys at young and adult stages.
  • Recordings were taken at different cortical depths to assess laminar distribution of neural activity.
  • Activity was analyzed during working memory tasks, focusing on delay intervals and discriminability.

Main Results:

  • Increased baseline firing rate observed in superficial cortical layers in adult compared to young stages.
  • Substantial increases in delay period activity detected in middle cortical layers post-adolescence.
  • Improved discriminability around the saccade period was most prominent in deeper cortical layers.

Conclusions:

  • Neurophysiological maturation during adolescence is not limited to superficial cortical layers.
  • Significant changes in working memory-related neural activity occur across multiple cortical depths, including intermediate layers.
  • These findings reveal a complex laminar pattern of neural maturation underlying cognitive improvements in adolescence.