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Mechanical factors driving cancer progression
Jessanne Y Lichtenberg1, Sydnie Tran1, Priscilla Y Hwang1
1Department of Biomedical Engineering, Virginia Commonwealth University, Richmond, VA, United States.
Advances in Cancer Research
|September 13, 2023
Summary
Collective invasion, a key step in tumor metastasis, involves coordinated cell migration. This review explores how the tumor microenvironment
Area of Science:
- Oncology
- Biophysics
- Cell Biology
Background:
- Tumor metastasis involves tumor cell migration.
- Collective invasion, where cell clusters migrate coordinately, is crucial but understudied.
- Biomechanical regulation of collective invasion is gaining research interest.
Conclusions:
- Understanding the biomechanical regulation of collective invasion is critical for deciphering tumor metastasis.
- The interplay between microenvironment mechanics and cell mechanosensing is key to coordinated cell migration.
- Further research using advanced model systems will continue to illuminate the mechanical underpinnings of tumor progression.
Keywords:
Cancer associated fibroblastsCollective invasionImmune cellsLeader cellsMechanical matrix cuesMechanosensingTumor microenvironmentMore Related Videos
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