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Current Practices in Pharmacogenomics.

Laura B Ramsey1, Cynthia A Prows2, Sonya Tang Girdwood3

  • 1Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, College of Medicine, University of Cincinnati, 3333 Burnet Avenue, MLC 6018, Cincinnati, OH 45229, USA; Division of Research in Patient Services, Cincinnati Children's Hospital Medical Center, College of Medicine, University of Cincinnati, 3333 Burnet Avenue, MLC 6018, Cincinnati, OH 45229, USA; Department of Pediatrics, University of Cincinnati College of Medicine, 3333 Burnet Avenue, MLC 9016, Cincinnati, OH 45529, USA.

Pediatric Clinics of North America
|September 13, 2023
PubMed
Summary
This summary is machine-generated.

Pharmacogenomics uses genetic information to personalize medication for children, improving effectiveness and reducing side effects. This approach, supported by guidelines, is increasingly used in pediatric care.

Keywords:
GenomicsGuidelinesPediatricsPharmacogenetics

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Area of Science:

  • Pharmacogenomics and Precision Medicine
  • Pediatric Pharmacology
  • Genetics in Healthcare

Background:

  • Pharmacogenomics optimizes medication by using genomic data to maximize drug efficacy and minimize toxicity.
  • While pediatric evidence is developing, pharmacogenomic principles are applied to medications used in children and adolescents.
  • Resources like the Clinical Pharmacogenetics Implementation Consortium (CPIC) and Pharmacogenomics Knowledgebase (PharmGKB) offer evidence-based guidelines and drug information.

Purpose of the Study:

  • To illustrate the clinical application of pharmacogenomic data in pediatric patient care.
  • To highlight the importance of pharmacogenomics in tailoring medication for children.
  • To provide accessible resources for pediatric healthcare providers regarding pharmacogenomic guidelines.

Main Methods:

  • A case-based approach was utilized to demonstrate pharmacogenomic data integration in pediatric clinical scenarios.
  • Review of existing evidence-based guidelines and drug label annotations from CPIC and PharmGKB.
  • Discussion of how pharmacogenomic information can inform pediatric dosing recommendations.

Main Results:

  • The case-based examples effectively illustrate the practical use of pharmacogenomic data in pediatric settings.
  • Availability of established guidelines facilitates the implementation of pharmacogenomics in pediatric care.
  • Pediatric healthcare facilities are beginning to integrate pharmacogenomic data for improved patient management.

Conclusions:

  • Pharmacogenomics offers a valuable strategy for optimizing medication therapy in pediatric populations.
  • The use of pharmacogenomic data can lead to improved therapeutic outcomes and enhanced patient safety in children.
  • Resources and guidelines are available to support the clinical implementation of pharmacogenomics in pediatric practice.