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Myocardial Infarction and Functional Outcome Assessment in Pigs
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Myocardial infarction impaired wall mechanics and hemodynamics in peripheral arteries

Qiang Xue1, Hongyu Shi2, Li Li3,4

  • 1Department of Cardiology, Yanan Hospital Affiliated to Kunming Medical University, Kunming, Yunnan, China.

Frontiers in Physiology
|September 14, 2023
PubMed

Insights

Myocardial infarction (MI) stiffened peripheral arteries and altered blood flow dynamics. These changes in wall stress are crucial for understanding heart failure progression after MI.

Area of Science:

  • Cardiovascular Physiology
  • Biomedical Engineering
  • Hemodynamics

Background:

  • Myocardial infarction (MI) negatively impacts cardiac function and peripheral arteries.
  • Understanding alterations in peripheral artery wall stress is key to deciphering MI-induced heart failure (HF) progression.

Purpose of the Study:

  • To investigate changes in normal and shear stresses within peripheral arteries following MI.
  • To analyze the impact of MI on arterial wall mechanics and hemodynamics.

Main Methods:

  • Myocardial infarction was induced in Wistar rats using coronary artery ligation.
  • In vivo and in vitro measurements were employed for wall mechanics and hemodynamic analysis.

Main Results:

  • MI significantly increased arterial wall stiffness in both carotid and femoral arteries.
  • Postoperative weeks 3-6 showed distinct changes in stiffness between elastic and muscular arteries.
  • Hemodynamic analysis revealed progressive deterioration of wall shear stress, oscillatory shear index, and relative residence time.

Conclusions:

  • MI induces significant changes in peripheral artery mechanics and hemodynamics.
  • These findings contribute to understanding the interplay between systemic circulation and peripheral vascular changes in MI-induced HF.

Keywords:
Womersley modelhemodynamicsmyocardial infarctionperipheral arterywall mechanics

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