Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Multiple Allele Traits

Multiple Allele Traits

The Concept of Multiple Allelism

Modern Molecular Taxonomy

Modern Molecular Taxonomy

Advancements in molecular biology have revolutionized the identification and characterization of bacteria, with multiple methods leveraging DNA sequencing for enhanced precision. As sequencing technologies improve and costs decline, these approaches are increasingly used in clinical, environmental, and evolutionary studies.Multilocus Sequence Typing (MLST) examines several housekeeping genes, essential chromosomal genes encoding cellular functions, to distinguish strains. Approximately...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

In Vivo Imaging With a Low-Cost MRI Scanner and Cloud Data Processing in Low-Resource Settings.

NMR in biomedicine·2026

Same author

Genome admixture analysis of 1,030 Ugandan infants with neonatal sepsis and hydrocephalus demonstrates geographical stratification of population disease risk.

medRxiv : the preprint server for health sciences·2026

Same author

Genomic evidence of convergence of multidrug resistance and enhanced virulence in carbapenem- and colistin-resistant <i>Klebsiella pneumoniae</i> from Turkey.

Microbiology spectrum·2026

Same author

Clonal dissemination of mcr-1.1-positive Escherichia coli ST10 among healthy children in geographically-distant cities.

American journal of infection control·2026

Same author

Tsunamis hiding in plain sight: spreading depression in clinical neurology.

Nature reviews. Neurology·2026

Same author

VDJdive and ECLIPSE enhance single-cell TCR sequencing analysis through the probabilistic resolution of ambiguous clonotypes.

bioRxiv : the preprint server for biology·2026

Search research articles

Related Experiment Video

Updated: Jun 18, 2026

A Quantitative Fitness Analysis Workflow

A Quantitative Fitness Analysis Workflow

Published on: August 13, 2012

mbQTL: an R/Bioconductor package for microbial quantitative trait loci (QTL) estimation.

Mercedeh Movassagh^1,2, Steven J Schiff², Joseph N Paulson³

¹Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA 02115, United States.

Bioinformatics (Oxford, England)

|September 14, 2023

Summary

The mbQTL R package links host genetic variants to microbial abundance using 16S rRNA and SNV/SNP data. This tool aids in understanding the human microbiome and its role in health and disease.

More Related Videos

QTL Mapping and CRISPR/Cas9 Editing to Identify a Drug Resistance Gene in Toxoplasma gondii

QTL Mapping and CRISPR/Cas9 Editing to Identify a Drug Resistance Gene in Toxoplasma gondii

Published on: June 22, 2017

Author Spotlight: AQRNA-seq Role in Mapping Small RNAs and Unraveling Protein Translation Mechanisms

Author Spotlight: AQRNA-seq Role in Mapping Small RNAs and Unraveling Protein Translation Mechanisms

Published on: February 2, 2024

Related Experiment Videos

Last Updated: Jun 18, 2026

A Quantitative Fitness Analysis Workflow

A Quantitative Fitness Analysis Workflow

Published on: August 13, 2012

QTL Mapping and CRISPR/Cas9 Editing to Identify a Drug Resistance Gene in Toxoplasma gondii

QTL Mapping and CRISPR/Cas9 Editing to Identify a Drug Resistance Gene in Toxoplasma gondii

Published on: June 22, 2017

Author Spotlight: AQRNA-seq Role in Mapping Small RNAs and Unraveling Protein Translation Mechanisms

Author Spotlight: AQRNA-seq Role in Mapping Small RNAs and Unraveling Protein Translation Mechanisms

Published on: February 2, 2024

Area of Science:

Genomics
Microbiome research
Bioinformatics

Background:

Large-scale studies collect host mutational profiles and microbiome data.
Integrating host genetics and microbial data offers insights into disease development and treatment responses.
16S ribosomal RNA (rRNA) sequencing and whole genome sequencing reveal the interplay between human genetics and microbial communities.

Purpose of the Study:

Introduce mbQTL, the first R package for integrating 16S rRNA sequencing with single-nucleotide variation (SNV) and single-nucleotide polymorphism (SNP) data.
Facilitate the identification of microbe-SNV pairs and their association with microbial abundance.

Main Methods:

The mbQTL package implements statistical methods for identifying microbe-SNV associations.
It includes relevant statistical measures and plotting functionalities for data interpretation.

Main Results:

The study introduces the mbQTL R package, a novel tool for analyzing host genetic variation and microbial communities.
The package integrates diverse data types, including 16S rRNA sequencing and SNV/SNP data.

Conclusions:

The mbQTL package provides a comprehensive framework for exploring microbe-quantitative trait loci (mbQTLs).
This tool is expected to advance research into the genetic underpinnings of the human microbiome and its impact on health and disease.