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Anterior segment complications after dexamethasone implantations:real world data
Yusuf Ayaz1, Çisil Erkan Pota2, İbrahim Başol1
1Department of Ophthalmology, Akdeniz University Medical Faculty, Antalya, Turkey.
International Ophthalmology
|September 14, 2023
Summary
This study evaluated the safety of dexamethasone implants for retinal diseases. The most common side effects were cataract progression and increased intraocular pressure (IOP), necessitating close IOP monitoring post-injection.
Area of Science:
- Ophthalmology
- Retinal Diseases
- Pharmacology
Background:
- Dexamethasone implants are used to treat various retinal diseases.
- Real-world data on the safety and complications of these implants is valuable.
Purpose of the Study:
- To evaluate the safety and anterior segment complications of intravitreal dexamethasone implants.
- To present real-world, long-term follow-up data on dexamethasone implant treatment.
Main Methods:
- Retrospective review of patients receiving intravitreal dexamethasone implants for retinal diseases.
- Data collected on complications, intraocular pressure (IOP), and cataract development.
- Mean follow-up of 24 months for 470 eyes across 383 patients.
Main Results:
- No complications in 328 eyes; 97 eyes (20.6%) developed increased IOP.
- Cataracts requiring surgery occurred in 55 phakic eyes (21.73%).
- Rare complications included implant dislocation and sterile endophthalmitis.
Conclusions:
- Cataract progression and elevated IOP are the most frequent side effects of dexamethasone implants.
- Patient diagnosis did not significantly impact side effect occurrence.
- Close monitoring of IOP is recommended after dexamethasone implant administration.
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