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Slide-type waveflex biosensor based on signal enhancement technology for alpha-fetoprotein detection.

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    This study introduces a novel WaveFlex Biosensor for detecting alpha-fetoprotein (AFP). This localized surface plasmon resonance (LSPR) biosensor enhances signal detection for accurate, rapid low-concentration sample analysis.

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    Area of Science:

    • Biomedical Engineering
    • Nanotechnology
    • Optical Sensing

    Background:

    • Accurate detection of low-concentration samples is crucial in diagnostics.
    • Optical fiber biosensors offer sensitive detection methods.
    • Signal enhancement is key to improving biosensor performance.

    Purpose of the Study:

    • To develop a signal-enhanced optical fiber biosensor for alpha-fetoprotein (AFP) detection.
    • To utilize localized surface plasmon resonance (LSPR) with a novel fiber structure and nanomaterials.
    • To achieve rapid and accurate measurement of low-concentration AFP samples.

    Main Methods:

    • Fabrication of a slide-type fiber structure (WaveFlex Biosensor) using multi-mode fiber (MMF) and multi-core fiber (MCF).
    • Functionalization of the fiber probe with gold nanoparticles (AuNPs), CeO2 nanoparticles, and C3N quantum dots to enhance LSPR signals.
    • Immobilization of AFP antibodies for specific AFP detection.

    Main Results:

    • The WaveFlex Biosensor demonstrated a sensitivity of 32 pm/(ng/mL) for AFP detection.
    • A limit of detection (LOD) of 6.65 ng/mL was achieved.
    • The signal enhancement from nanomaterials improved biosensor sensitivity and detection speed.

    Conclusions:

    • The developed signal-enhanced AFP WaveFlex Biosensor shows significant potential for rapid and accurate clinical diagnostics.
    • The combination of LSPR, a unique fiber structure, and nanomaterials provides a robust platform for biosensing.
    • This technology facilitates improved detection of low-concentration biomarkers like AFP.