The latest perspectives of small molecules FMS kinase inhibitors

Area of Science:

• Biochemistry
• Pharmacology
• Oncology

Background:

• FMS kinase, a type III tyrosine kinase receptor, is implicated in various diseases including cancers, inflammatory, neurodegenerative, and bone disorders.
• Understanding FMS kinase's role is crucial for developing targeted therapies.

Purpose of the Study:

• To review the pathophysiological pathways of FMS kinase in different diseases.
• To discuss recent developments in FMS kinase monoclonal antibodies and inhibitors over the last five years.
• To classify FMS inhibitors based on their core chemical structures.

Main Methods:

• Literature review of pathophysiological pathways and FMS kinase inhibitors.
• Analysis of biological and biochemical features of inhibitors (binding interactions, SAR, selectivity, potency).
• Focus on compounds in advanced clinical investigation and FDA-approved drugs.

Main Results:

• Detailed discussion of FMS kinase's role in disease pathophysiology.
• Comprehensive overview of FMS kinase inhibitors developed in the last five years.
• Classification of inhibitors into pyridine, pyrrolopyridine, pyrazolopyridine, quinoline, and pyrimidine derivatives.

Conclusions:

• FMS kinase inhibitors represent a promising therapeutic strategy for various diseases.
• Recent advancements have yielded potent and selective inhibitors with clinical potential.
• Chemical structure-based classification aids in understanding inhibitor diversity and development.