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Related Concept Videos

Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids01:25

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Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
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Antiasthma Drugs: Leukotriene Modifiers01:19

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Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
Leukotriene modifiers work through two distinct mechanisms:
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Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
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Drugs Used in Lower Respiratory Disorders: Overview01:17

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Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
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COPD: Management Using Bronchodilators and Corticosteroids01:26

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Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
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Asthma-IV: Diagnostic and Management01:30

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The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
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Updated: Jul 16, 2025

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
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Topical and Oral Roflumilast in Dermatology: A Narrative Review.

M Mansilla-Polo1, E Gimeno2, D Morgado-Carrasco3

  • 1Servicio de Dermatología, Hospital Universitario y Politécnico La Fe, Valencia, España; Instituto de Investigación Sanitaria La Fe (IIS La Fe), Valencia, España.

Actas Dermo-Sifiliograficas
|September 14, 2023
PubMed
Summary

Roflumilast, a phosphodiesterase-4 inhibitor, shows promise in dermatology for treating conditions like psoriasis and seborrheic dermatitis. Its favorable safety profile and cost-effectiveness make it a valuable therapeutic option.

Keywords:
ApremilastDermatologyDermatologíaFosfodiesterasaOff-labelPhosphodiesterasePsoriasisRoflumilast

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Area of Science:

  • Dermatology
  • Pharmacology

Background:

  • Oral roflumilast is approved for COPD and chronic bronchitis.
  • Topical roflumilast treats plaque psoriasis and seborrheic dermatitis.
  • Off-label dermatological uses are increasingly reported.

Purpose of the Study:

  • To review the pharmacokinetics and pharmacodynamics of topical and oral roflumilast.
  • To discuss approved and off-label dermatological applications.
  • To evaluate roflumilast's safety and cost-effectiveness.

Main Methods:

  • Literature review of pharmacokinetic and pharmacodynamic data.
  • Analysis of clinical studies and case reports on roflumilast in dermatology.
  • Comparison with existing dermatological treatments.

Main Results:

  • Roflumilast demonstrates efficacy in plaque psoriasis and seborrheic dermatitis.
  • Successful off-label use reported for hidradenitis suppurativa, aphthosis, eczema, lichen planus, and Behçet disease.
  • Favorable safety profile comparable to apremilast, with lower cost.

Conclusions:

  • Roflumilast is a versatile and cost-effective agent for various dermatological conditions.
  • Its established safety and efficacy support its consideration in dermatological practice.
  • Further research into off-label uses may expand its therapeutic role.