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Updated: Jul 16, 2025

Synthesis of Esters Via a Greener Steglich Esterification in Acetonitrile
Published on: October 30, 2018
DCID-mediated esterification of carboxylic acids with alcohols under mild conditions
Farzaneh Nasiri1, Javad Mokhtari1, Salman Taheri2
1Department of Chemistry, Science and Research Branch, Islamic Azad University PO Box 14515/775 Tehran Iran j.mokhtari@srbiau.ac.ir.
Abstract:
DCID (Dichloroimidazolidinedione) 2 is used as a novel coupling reagent for the esterification of carboxylic acids with alcohols at room temperature. The reaction represents the first DCID-promoted esterification under mild conditions with good to excellent yields. Reactions can proceed smoothly with those bearing electron-withdrawing and donating group(s) on the carboxylic acids and benzyl alcohols at ambient temperature. Furthermore, we proposed a plausible mechanism and confirmed it by isolating and characterizing intermediates 3a and 7. The structures of the synthesized compounds were confirmed by comparison of melting points and NMR spectra.
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