Multicomponent reaction (MCR) for constructing bis-spirocyclohexane skeletons using β-nitrostyrene derived MBH
Veera Babu Gudise1, Shaik Anwar1
1Department of Chemistry, School of Applied Sciences and Humanities, Vignan's Foundation for Science, Technology and Research-VFSTR, (Deemed to be University) Vadlamudi Guntur 522 213 Andhra Pradesh India shaikanwarcu@gmail.com drsa_sh@vignan.ac.in (+91)-8632344700.
Abstract:
An AB2C type four-component quadruple cascade reaction has been established between nitroallylic MBH acetate, 1,3-indanedione and aldehyde for generating bis-spirocyclohexanes. This reaction progressed in an unusual [1 + 1 + 1 + 3] annulation manner via a Knoevenagel/Michael/Michael/Michael sequence, resulting in the generation of three/four chiral centres, and two all-carbon quaternary centres through the formation of 3 new C-C bonds.
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