Relationship between bone marrow adipose tissue and kidney function in postmenopausal women

Area of Science:

• Bone biology and metabolism
• Nephrology
• Radiology

Background:

• Bone marrow adipose tissue (BMAT) is linked to aging, osteoporosis, and chronic kidney disease (CKD).
• The relationship between BMAT and kidney function in postmenopausal women remains understudied.
• This research investigates the association between BMAT and kidney function in this demographic.

Purpose of the Study:

• To determine if a relationship exists between proton density fat fraction (PDFF) and kidney function in postmenopausal women.
• To explore the association between estimated glomerular filtration rate (eGFR) and BMAT.

Main Methods:

• Cross-sectional study of 199 postmenopausal women from the ADIMOS cohort.
• Measured eGFR using CKD-EPI equation and PDFF at lumbar spine and proximal femur via WFI MRI.
• Conducted DXA scans and measured sclerostin and cFGF23 levels.

Main Results:

• No significant differences in lumbar spine or proximal femur PDFF were found across eGFR categories after adjusting for confounders.
• Initial unadjusted analyses showed some differences in lumbar spine PDFF between eGFR groups, but these did not persist.
• Sclerostin and cFGF23 levels did not mediate the observed associations.

Conclusions:

• This study found no evidence of an association between kidney function and bone marrow adiposity in postmenopausal women.
• The findings suggest that BMAT, as measured by PDFF, is not significantly related to kidney function in this population.
• Further research may be needed to explore potential indirect relationships or different measurement techniques.