Autologous concentrated growth factor mediated accelerated bone healing in root-end microsurgery: A multicenter...

Area of Science:

• Dentistry
• Regenerative Medicine
• Oral Surgery

Background:

• Concentrated growth factor (CGF) is an autologous platelet concentrate known for promoting tissue regeneration and possessing anti-inflammatory effects.
• Root-end microsurgery is a procedure to treat persistent periapical lesions.

Purpose of the Study:

• To evaluate the efficacy of CGF in enhancing bone healing when used with root-end microsurgery.
• To compare bone regeneration outcomes between patients receiving CGF and a control group.

Main Methods:

• A randomized multicenter trial involving 24 adult patients undergoing root-end microsurgery.
• CGF was implanted into the bone cavity post-root-end filling; control group received no CGF.
• Clinical, periapical radiographic, and cone-beam computed tomography (CBCT) evaluations were performed at various postoperative intervals.

Main Results:

• No significant difference in overall treatment success rates between CGF and control groups at 12 months (91.7% vs. 83.3%).
• The CGF group demonstrated a significantly higher lesion volume reduction rate (75.6%) compared to the control group (61.0%) at 6 months via CBCT.

Conclusions:

• Autologous CGF, when combined with root-end microsurgery, accelerates bone lesion reduction.
• Using autologous blood products like CGF to stimulate healing is a promising adjunct to infection source removal in root-end microsurgery.