Related Experiment Video
Updated: Jul 16, 2025
09:07
Detecting the Ligand-binding Domain Dimerization Activity of Estrogen Receptor Alpha Using the Mammalian Two-Hybrid Assay
Published on: December 19, 2018
6.4K
AIB1/SRC-3/NCOA3 function in estrogen receptor alpha positive breast cancer
Amber J Kiliti1,2, Ghada M Sharif1, Mary Beth Martin1,2
1Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, United States.
Frontiers in Endocrinology
|September 15, 2023
Summary
The steroid receptor coactivator AIB1 is an oncogene that drives breast cancer progression and endocrine therapy resistance. Targeting AIB1 offers a potential therapeutic strategy for breast cancer treatment.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Estrogen receptor alpha (ERα) is crucial for initiating and progressing most breast cancers.
- Steroid receptor coactivator AIB1 amplifies ERα-mediated gene transcription.
- AIB1 is an oncogene overexpressed in some breast cancers, contributing to tumor progression and therapy resistance.
Purpose of the Study:
- To review the normal and pathological functions of AIB1 in breast cancer.
- To examine AIB1's ERα-dependent and ERα-independent actions.
- To discuss AIB1's genomic conservation, protein evolution, and therapeutic targeting.
Main Methods:
- Literature review of AIB1's role in ERα signaling.
- Analysis of AIB1's oncogenic functions in breast cancer.
- Examination of AIB1's evolutionary and genomic aspects.
Main Results:
- AIB1 acts as an oncogene, promoting breast cancer via ERα-dependent and -independent pathways.
- Overexpression of AIB1 correlates with tumor progression and resistance to endocrine therapy.
- AIB1's conserved functions and evolutionary trajectory highlight its significance.
Conclusions:
- AIB1 is a key player in breast cancer pathogenesis and endocrine resistance.
- Targeting AIB1 presents a promising therapeutic avenue for breast cancer treatment.
- Understanding AIB1's multifaceted roles is essential for developing effective cancer therapies.
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