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Updated: Jul 16, 2025

Synthesis of Esters Via a Greener Steglich Esterification in Acetonitrile
Published on: October 30, 2018
Nickel-Catalyzed Metathesis between Carboxylic Acids and Thioesters: A Direct Access to Thioesters
Qiumin Xie1, Anhui Wei1, Ziding Liu1
1School of Science, Anhui Agricultural University, Hefei 230036, P. R. China.
Abstract:
We describe a unique strategy for generating thioesters from carboxylic acids and thioesters. This transformation features operational simplicity and high step-economy, wherein the -SR moiety of thioesters was smoothly transferred to carboxylic acid from thioacetates as the starting material. Various substrates with different levels of electronic nature were all applicable to this reaction, furnishing thioesters in moderate to outstanding yields. According to the preliminary mechanistic studies, the anhydride intermediates may be involved in the present reaction.
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