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Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

618
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
618
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

477
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
477
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

559
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
559

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Related Experiment Video

Updated: Jul 16, 2025

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
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AIROGS: Artificial Intelligence for Robust Glaucoma Screening Challenge.

Coen de Vente, Koenraad A Vermeer, Nicolas Jaccard

    IEEE Transactions on Medical Imaging
    |September 15, 2023
    PubMed
    Summary
    This summary is machine-generated.

    Artificial intelligence (AI) shows promise for early glaucoma detection using color fundus photographs. The AIROGS challenge developed robust AI algorithms that perform comparably to experts, even with low-quality images.

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    Area of Science:

    • Ophthalmology
    • Medical Imaging
    • Artificial Intelligence

    Background:

    • Early glaucoma detection is crucial for preventing vision loss.
    • Artificial intelligence (AI) offers a cost-effective method for analyzing color fundus photographs (CFPs) for glaucoma screening.
    • Current AI models struggle with real-world data, including out-of-distribution and low-quality images, leading to decreased performance.

    Purpose of the Study:

    • To address the performance limitations of AI in real-world glaucoma screening.
    • To introduce the Artificial Intelligence for Robust Glaucoma Screening (AIROGS) challenge.
    • To foster the development of AI algorithms robust to ungradable and unexpected image data.

    Main Methods:

    • The AIROGS challenge utilized a large dataset of approximately 113,000 images from 60,000 patients across 500 screening centers.
    • Evaluated solutions from 14 participating teams.
    • Assessed algorithm performance on detecting ungradable images and tested robustness on external public datasets.

    Main Results:

    • The top AI algorithms achieved performance comparable to 20 expert ophthalmologists and optometrists.
    • The highest-scoring team demonstrated high accuracy in on-the-fly detection of ungradable images (AUC 0.99).
    • Many developed algorithms exhibited robust performance across multiple public datasets.

    Conclusions:

    • Robust AI-enabled glaucoma screening is feasible, even with challenging real-world image data.
    • The AIROGS challenge successfully promoted the development of more resilient AI models for glaucoma detection.
    • AI holds significant potential to enhance the accessibility and accuracy of widespread glaucoma screening programs.