Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Targets for Drug Action: Overview01:26

Targets for Drug Action: Overview

6.4K
Drugs target macromolecules to modify ongoing cellular processes. Primary drug targets include receptors, ion channels, transporters, and enzymes.
Receptors are either membrane-spanning or intracellular proteins, which upon binding a ligand, get activated and transmit the signal downstream to elicit a response. Drugs bind receptors, either mimicking the action of endogenous ligands or blocking the receptor activity to bring about a modified response. Nearly 35% of approved drugs target the G...
6.4K
Drug Discovery: Overview01:26

Drug Discovery: Overview

8.0K
Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
8.0K
Therapeutic Index01:13

Therapeutic Index

4.3K
The therapeutic index of a drug is a key parameter in pharmacology that quantifies the relative safety of a drug by calculating the ratio between the dose that causes toxicity in half the population (50%) to the dose that proves to be effective for half the population (50%). It provides a spectrum of doses for a particular drug ranging from effective to potentially toxic. To illustrate, consider an anticoagulant agent like warfarin. It possesses a narrow window within its therapeutic index to...
4.3K
Transducer Mechanism: Enzyme-Linked Receptors01:27

Transducer Mechanism: Enzyme-Linked Receptors

2.5K
Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:
2.5K
Principles of Drug Action01:24

Principles of Drug Action

6.1K
Drugs are chemical substances that modify biological responses by interacting with macromolecular targets such as receptors, ion channels, transporters, and enzymes. Pharmacodynamics describes the course of action of drugs leading to the physiological effect at a specific site in the body.
Drugs can be agonists or antagonists. Like the endogenous ligands, agonists always bind and activate the target to produce a cellular response. Agonist binding induces a conformational change which in turn...
6.1K
Structure-Activity Relationships and Drug Design01:28

Structure-Activity Relationships and Drug Design

764
Drug design is a dynamic field that involves discovering and developing new medications based on specific biological targets. This process heavily relies on structure-activity relationships (SAR) and quantitative structure-activity relationships (QSAR) to guide the design and optimization of efficient drugs.
SAR studies the intricate relationship between a drug's chemical structure and biological activity. It focuses on understanding how modifications to a drug's structure can influence...
764

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Facilitating structure-based drug discovery with an artificial intelligence-driven virtual screening platform.

Nature protocols·2026
Same author

BioTD: An Online Database of Biotoxins.

Journal of chemical information and modeling·2026
Same author

An Iron-Complement Network Model of Thromboinflammation and Humoral Immune Remodeling in Severe COVID-19.

Current issues in molecular biology·2026
Same author

Revisiting ADMET prediction reliability under real-world challenges in the foundation model era.

Journal of cheminformatics·2026
Same author

An integrative meta-analysis of SARS-CoV-2 RNA-protein interactomes identifies conserved host factors shared with other RNA viruses.

Briefings in functional genomics·2026
Same author

Research progress on active ingredients of traditional Chinese medicine in the treatment of asthenozoospermia.

Frontiers in reproductive health·2026

Related Experiment Video

Updated: Jul 16, 2025

A Semi-Quantitative Drug Affinity Responsive Target Stability DARTS assay for studying Rapamycin/mTOR interaction
00:05

A Semi-Quantitative Drug Affinity Responsive Target Stability DARTS assay for studying Rapamycin/mTOR interaction

Published on: August 27, 2019

16.4K

TTD: Therapeutic Target Database describing target druggability information.

Ying Zhou1,2,3, Yintao Zhang1, Donghai Zhao1

  • 1College of Pharmaceutical Sciences, The Second Affiliated Hospital, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310058, China.

Nucleic Acids Research
|September 15, 2023
PubMed
Summary

Drug target discovery relies on druggability analysis. The Therapeutic Target Database (TTD) systematically reviewed targets, classifying druggability characteristics to aid innovative drug development.

More Related Videos

Author Spotlight: Streamlining Protein Target Prediction and Validation via Molecular Docking and CETSA
10:21

Author Spotlight: Streamlining Protein Target Prediction and Validation via Molecular Docking and CETSA

Published on: February 23, 2024

2.6K
A Data Integration Workflow to Identify Drug Combinations Targeting Synthetic Lethal Interactions
07:40

A Data Integration Workflow to Identify Drug Combinations Targeting Synthetic Lethal Interactions

Published on: May 27, 2021

4.2K

Related Experiment Videos

Last Updated: Jul 16, 2025

A Semi-Quantitative Drug Affinity Responsive Target Stability DARTS assay for studying Rapamycin/mTOR interaction
00:05

A Semi-Quantitative Drug Affinity Responsive Target Stability DARTS assay for studying Rapamycin/mTOR interaction

Published on: August 27, 2019

16.4K
Author Spotlight: Streamlining Protein Target Prediction and Validation via Molecular Docking and CETSA
10:21

Author Spotlight: Streamlining Protein Target Prediction and Validation via Molecular Docking and CETSA

Published on: February 23, 2024

2.6K
A Data Integration Workflow to Identify Drug Combinations Targeting Synthetic Lethal Interactions
07:40

A Data Integration Workflow to Identify Drug Combinations Targeting Synthetic Lethal Interactions

Published on: May 27, 2021

4.2K

Area of Science:

  • Pharmacology and Drug Development
  • Computational Biology and Cheminformatics

Background:

  • Identifying effective drug targets is crucial for developing novel therapeutics.
  • Druggability analysis assesses a target's potential to be modulated by drug-like molecules.

Purpose of the Study:

  • To systematically collect and categorize druggability characteristics of drug targets.
  • To provide a comprehensive resource for facilitating drug target discovery and validation.

Main Methods:

  • Systematic review of targets within the Therapeutic Target Database (TTD).
  • Classification of nine druggability characteristic categories from three perspectives: molecular interaction/regulation, human system profile, and cell-based expression variation.
  • Analysis of 426 successful, 1014 clinical trial, 212 preclinical/patented, and 1479 literature-reported targets.

Main Results:

  • Established druggability characteristics for a large cohort of drug targets.
  • Categorized targets based on molecular, systemic, and cellular profiles.
  • The Therapeutic Target Database (TTD) now includes extensive druggability data.

Conclusions:

  • The TTD provides a valuable, accessible resource for exploring druggability characteristics.
  • Facilitates the discovery and validation of innovative drug targets in modern drug development.
  • Advancements in technology and collaborative efforts enhance the utility of such databases.