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Updated: Jul 16, 2025

Transient Middle Cerebral Artery Occlusion Model of Neonatal Stroke in P10 Rats
Published on: April 21, 2017
[Arterial ischemic stroke in childhood]
María Celeste Buompadre1, Gabriel González Rabelino2
1Servicio de Neurología Infantil, Hospital de Pediatría Prof. Dr. Juan P Garrahan, Buenos Aires, Argentina.
Insights
Pediatric arterial ischemic stroke requires faster hyperacute treatment. Current treatments focus on anticoagulation for cardio-embolic and prothrombotic conditions, and antiplatelet therapy for arteriopathies.
Area of Science:
- Neurology
- Pediatrics
- Cardiology
Abstract:
Despite advances in the identification and recognition of risk factors for pediatric arterial ischemic stroke, little progress has been made in hyperacute treatment. The most frequent risk factors are arteriopathies, cardiopathies, and thrombophilia. Early confirmation with neuroradiological studies is key to consider reperfusion therapies, which have limited evidence in pediatrics but a good safety profile. There is consensus on the use of anticoagulation in cardio-embolic and prothrombotic diseases, and antiplatelet therapy in arteriopathies. The future challenge is to improve coordination between prehospital services and specialized stroke centers to improve therapeutic management in the hyperacute stage and reduce morbidity and mortality.
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