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Updated: Jul 16, 2025

Author Spotlight: Advancements in Hypoxia-Sensitive CAR-T Therapy for Enhanced Cancer Immunotherapy
Published on: June 14, 2024
Building smart CAR T cell therapies: The path to overcome current challenges
Qi Cai1, Sarah Warren1, Violena Pietrobon1
1Kite Pharma, 2400 Broadway Boulevard, Santa Monica, CA 90404, USA.
Abstract:
Successful implementation of adoptive cell therapy (ACT) of cancer requires comprehensively addressing biological and practical challenges. This approach has been largely overlooked, resulting in a gap between the potential of ACT and its actual effectiveness. We summarize the most promising technical strategies in creating an "ideal" ACT product, focusing on chimeric antigen receptor (CAR)-engineered cells. Since many requirements for effective ACT are common to most cancers, what we outline here might have a broader impact.
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