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Breast Cancer Risk Reduction: Current Status and Emerging Trends to Increase Efficacy and Reduce Toxicity of
1Department of Surgery, Feinberg School of Medicine of Northwestern University, 303 East Superior Street, Chicago, IL 60614, USA.
Surgical Oncology Clinics of North America
|September 15, 2023
Summary
Primary breast cancer prevention faces challenges with provider prioritization and patient side effects. Emerging strategies include better risk prediction and optimized medication to improve prevention for high-risk women.
Area of Science:
- Oncology
- Genetics
- Radiology
Background:
- Primary prevention of breast cancer is crucial, with established efficacy of antiestrogens.
- Implementation is hindered by low provider prioritization and patient reluctance due to side effects.
Purpose of the Study:
- To explore emerging solutions for breast cancer primary prevention.
- To address challenges in implementing antiestrogen therapy for high-risk women.
- To discuss advancements in risk prediction and treatment optimization.
Main Methods:
- Utilizing polygenic risk scores for improved risk estimation.
- Applying radiomics to screening mammograms for enhanced detection.
- Investigating medication dose optimization to minimize toxicity.
- Pursuing agents for estrogen receptor negative or HER2-positive tumors.
Main Results:
- Polygenic risk scores and radiomics offer improved breast cancer risk assessment.
- Medication dose optimization can mitigate side effects, enhancing patient adherence.
- Research is ongoing to identify agents targeting specific tumor subtypes.
Conclusions:
- Personalized medical risk reduction for breast cancer requires accurate prediction of tumor subtypes.
- Advancements in risk stratification and targeted therapies are key to overcoming current prevention barriers.
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