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Cindy X Zhang1, Samuel L M Arnold2

  • 1University of Washington, United States.

Drug Metabolism and Disposition: the Biological Fate of Chemicals
|September 15, 2023
PubMed
Summary
This summary is machine-generated.

Physiologically based pharmacokinetic (PBPK) modeling can predict how diarrhea affects oral drug absorption. This approach helps understand suboptimal drug exposure and treatment failures caused by diarrheal diseases.

Keywords:
diarrheaphysiologically-based pharmacokinetic modeling/PBPK

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Area of Science:

  • Pharmacokinetics
  • Drug Metabolism and Transport
  • Systems Pharmacology

Background:

  • Physiologically based pharmacokinetic (PBPK) modeling integrates drug and physiological parameters for pharmacokinetic predictions.
  • PBPK is widely used for drug-drug interactions, organ impairment, and special population studies.
  • The impact of diarrheal diseases on oral drug pharmacokinetics is an underutilized application of PBPK.

Purpose of the Study:

  • To review the key processes of oral drug absorption.
  • To examine how diarrheal diseases impact these absorption processes.
  • To discuss the potential and challenges of using PBPK for predicting these impacts.

Main Methods:

  • Literature review of physiological changes during diarrheal diseases.
  • Identification of key parameters for oral drug absorption in PBPK models.
  • Analysis of existing PBPK applications and their relevance to diarrheal disease.

Main Results:

  • Diarrheal diseases cause physiological changes affecting oral drug absorption.
  • Altered drug absorption can lead to suboptimal drug exposure and treatment failure.
  • PBPK modeling offers a valuable in silico tool to predict these pharmacokinetic alterations.

Conclusions:

  • PBPK modeling holds significant potential for predicting the impact of diarrheal diseases on oral drug pharmacokinetics.
  • Understanding these impacts is crucial for optimizing drug therapy in affected populations.
  • Further research and application of PBPK are needed to address challenges in this area.