Related Experiment Video

Updated: Jul 16, 2025

Measuring the Carotid to Femoral Pulse Wave Velocity Cf-PWV to Evaluate Arterial Stiffness
05:51

Measuring the Carotid to Femoral Pulse Wave Velocity Cf-PWV to Evaluate Arterial Stiffness

Published on: May 3, 2018

17.6K

Home systolic blood pressure time in therapeutic range and cardiovascular risk: the practitioner-based nationwide

Kazuomi Kario1, Naoko Tomitani2, Yukie Okawara2

  • 1Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, Tochigi, Japan. kkario@jichi.ac.jp.

Hypertension Research : Official Journal of the Japanese Society of Hypertension
|September 15, 2023
PubMed

Insights

Maintaining a stable home systolic blood pressure (SBP) within the therapeutic range is crucial. Lower time in therapeutic range (TTR) for home SBP significantly increases the risk of cardiovascular and stroke events.

Area of Science:

  • Cardiology
  • Hypertension Research
  • Clinical Trials

Background:

  • Time in therapeutic range (TTR) for office systolic blood pressure (SBP) predicts cardiovascular events.
  • The clinical significance of TTR for home SBP remains uninvestigated.

Purpose of the Study:

  • To determine the association between TTR of home SBP and cardiovascular events.
  • To assess cardiovascular event risk across different quartiles of home SBP TTR.

Main Methods:

  • Analysis of data from The Japan Morning Surge-Home Blood Pressure (J-HOP) study.
  • Defined therapeutic range for home SBP as 100-135 mmHg during a 13-day baseline.
  • Categorized participants into quartiles based on home SBP TTR and followed them for a mean of 6.3 years.

Main Results:

  • Lower home SBP TTR was associated with increased risk of total cardiovascular events (HR 1.74 for lowest vs. highest quartile).
  • A 10% decrease in home SBP TTR correlated with a 4% increase in total cardiovascular event risk.
  • Lower TTR significantly increased stroke risk (HR 2.11 for lowest vs. highest quartile; 9% increase per 10% TTR decrease).

Conclusions:

  • Home SBP TTR is a significant predictor of cardiovascular and cerebrovascular events.
  • Achieving stable home SBP and minimizing blood pressure variability are critical for reducing event risk.

Keywords:
Blood pressure variabilityCardiovascular riskHome blood pressureStrokeTime in therapeutic range

More Related Videos

Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome06:04

Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome

Published on: September 27, 2024

935
Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research08:42

Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research

Published on: October 22, 2014

27.4K

Related Concept Videos

Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
25
Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
14
Hypertension and Regulation of Blood Pressure01:18

Hypertension and Regulation of Blood Pressure

Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
2.1K
Blood Pressure01:24

Blood Pressure

The movement of blood in a human body, commonly referred to as blood flow, is determined by the volume of blood that traverses a certain section of the bodily system per unit time. It is the rhythmic contraction of the heart's ventricles that primarily instigates this movement. As the ventricles contract, blood is forced into the prominent arteries, which then flow from areas of greater pressure to lower pressure areas. This movement continues into smaller arteries and arterioles and...
3.2K
Measurement of Blood Pressure01:17

Measurement of Blood Pressure

Assessing blood pressure is a standard procedure executed in virtually all medical environments. The method utilized today was established over a hundred years ago by an innovative Russian doctor, Dr. Nikolai Korotkoff. The soft ticking noise, known as Korotkoff sounds, heard while taking blood pressure readings results from turbulent blood flow within the vessels. The apparatus required for this procedure includes a sphygmomanometer, a blood pressure cuff attached to a gauge, and a...
1.0K
Hypertension I: Introduction01:28

Hypertension I: Introduction

Hypertension is a widespread, long-term medical condition where blood pressure in the arteries remains elevated. It is characterized by systolic blood pressure readings of 130 mm Hg or above or diastolic blood pressure (DBP) readings of 80 mm Hg or higher. Unmanaged hypertension poses significant health risks, making the distinction between primary (or essential) hypertension and secondary hypertension crucial, as their management and implications vary.Primary HypertensionPrimary hypertension,...
16