Fixed Combination for the Treatment of Dyslipidaemia

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Nicola Ferri1,2, Massimiliano Ruscica3,4, Raul D Santos5,6

  • 1Department of Medicine (DIMED), University of Padova, Via Giustiniani 2, 35128, Padua, Italy. nicola.ferri@unipd.it.

Current Atherosclerosis Reports
|September 15, 2023
PubMed

Insights

Fixed-dose lipid-lowering combinations improve adherence and control plasma lipids in high-risk patients. These combinations, including statins/ezetimibe and bempedoic acid/ezetimibe, offer better therapeutic options for atherosclerotic cardiovascular diseases (ASCVD).

Area of Science:

  • Cardiology
  • Pharmacology
  • Lipid Metabolism

Background:

  • Epidemiological studies show high-risk patients often fail to meet lipid targets.
  • Atherosclerotic cardiovascular diseases (ASCVD) remain a significant health burden.

Purpose of the Study:

  • To review the role of fixed-dose combination lipid-lowering therapies.
  • To evaluate their efficacy in patients at high and very-high ASCVD risk.

Main Methods:

  • Review of current literature on fixed-dose combination therapies.
  • Analysis of clinical trial data for statin/ezetimibe, bempedoic acid/ezetimibe, and statin/fibrate combinations.

Main Results:

  • Moderate-intensity statin/ezetimibe is non-inferior to high-intensity statin monotherapy for cardiovascular outcomes.
  • Fixed-dose combinations show improved adherence compared to separate prescriptions.
  • Bempedoic acid/ezetimibe combination is superior to monotherapy for LDL-C reduction and hs-CRP.
  • Fenofibrate/atorvastatin combination effectively lowers triglycerides compared to monotherapies.

Conclusions:

  • Fixed-dose lipid-lowering combinations enhance therapy adherence and plasma lipid control.
  • These combinations represent a valuable strategy to manage ASCVD risk.
  • Further research is needed to confirm cardiovascular outcome benefits in high-risk populations.
Abstract

Keywords:
Bempedoic acidCombinationsEzetimibeFenofibratePolypillStatins

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