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Updated: Jul 16, 2025

Non-Invasive Modulation and Robotic Mapping of Motor Cortex in the Developing Brain
Published on: July 1, 2019
Application of non-invasive neuromodulation in children with neurodevelopmental disorders to improve their sleep
Aníbal Báez-Suárez1, Iraya Padrón-Rodríguez2, Elizabeth Castellano-Moreno2
1University of Las Palmas de Gran Canaria, Las Palmas, Spain. anibal.baez@ulpgc.es.
Insights
Non-invasive neuromodulation using microcurrents effectively improved sleep and constipation in children with neurodevelopmental disorders. This safe treatment offers a promising intervention for common symptoms in this population.
Area of Science:
- Neurology
- Pediatrics
- Biomedical Engineering
Background:
- Children with neurodevelopmental disorders often experience significant variability in clinical presentation.
- Constipation and poor sleep quality are prevalent issues in this population.
- Limited research exists on specific interventions for these common symptoms.
Purpose of the Study:
- To evaluate the effectiveness and safety of non-invasive neuromodulation.
- To assess improvements in constipation and sleep quality in children with neurodevelopmental disorders.
Main Methods:
- A cross-sectional study included 23 minors (ages 2-16).
- Participants received 60-minute microcurrent device sessions, 3 times/week for 4 weeks.
- Non-invasive neuromodulation involved surface-applied microcurrent electrostimulation via gloves and anklets.
Main Results:
- No adverse events were reported during the study.
- Significant improvements were observed in defecation frequency and type.
- Sleep duration increased from 7.35 to 9.09 hours, and sleep interruptions decreased (p < .001).
Conclusions:
- Microcurrents represent a safe and effective treatment for improving sleep and constipation in children with neurodevelopmental disorders.
- Further research is warranted to achieve statistically significant results and explore broader applications.
Background:
Children with neurodevelopmental disorders have a very wide clinical variability. A common prevalent factor is problems with stool and sleep quality. Currently, there are multiple studies related to their evaluation, but not so much related to a specific intervention. The aim was to evaluate the effectiveness and safety of the application of non-invasive neuromodulation as a treatment in children with neurodevelopmental disorders to improve constipation and quality of sleep.
Methods:
A total of 23 minors aged between 2 and 16 were included in this cross-sectional study. All participants were applied the microcurrent device for 60 min, 3 times per week for a total of 4 weeks. The technique was based on non-invasive neuromodulation using a surface-applied microcurrent electrostimulation device that administers an external, imperceptible, pulsed electrical stimulation. It is applied to the extremities, in a coordinated manner, using gloves and anklets connected with electrodes to a control console. Sleep latency and microarousals were evaluated through a sleep diary. To assess the evolution and type of defecation, the adapted and validated version in Spanish of the Bristol Stool Form Scale was used.
Results:
No adverse events occurred during the study and no incidences were registered. Clinically relevant improvements were registered in defecation frequency and type as well as in sleep related parameters. An increase in the hours of sleep was registered, from 7,35 (0,83) to 9,09 (1,35), and sleep interruptions decreased from 3,83 (1,95) to 1,17 (1,11), (p < .001).
Conclusion:
Microcurrents can be used as an effective and safe treatment to improve quality of sleep and constipation in children with neurodevelopmental disorders. More studies are needed in order to obtain statistically significant results.
Trial Registration:
ClinicalTrials.gov ID: NCT05265702.
First Registration:
03/03/2022 PROTOCOL: https://clinicaltrials.gov/ct2/show/NCT05265702?term=baez+suarez&draw=2&rank=4.
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