Related Experiment Video
Updated: Jul 16, 2025
10:28
Isolation, Expansion, and Adipogenic Induction of CD34+CD31+ Endothelial Cells from Human Omental and Subcutaneous Adipose Tissue
Published on: July 17, 2018
11.9K
Association between adiposity and facial aging: results from a Mendelian randomization study
1Department of Plastic and Cosmetic Surgery, Nanfang Hospital, Southern Medical University, 1838 Guangzhou North Road, Guangzhou, 510515, Guangdong, People's Republic of China.
European Journal of Medical Research
|September 15, 2023
Summary
This study reveals a causal link between increased adiposity and facial aging. Our findings suggest that higher body mass index, body fat percentage, and waist circumference contribute to facial aging.
Area of Science:
- Genetics
- Epidemiology
- Aging Research
Background:
- Facial aging has psychological implications, especially with global population aging.
- Observational studies suggest a correlation between facial aging and increased adiposity.
- Existing research faces challenges in establishing causality due to confounding factors.
Purpose of the Study:
- To investigate the potential causal effect of facial aging on obesity risk.
- To examine the relationship between facial aging and body mass index (BMI), body fat percentage (BF%), and waist circumference (WC).
Main Methods:
- A 2-sample Mendelian randomization (MR) study was conducted.
- Genetic instruments from the IEU OpenGWAS project for facial aging were utilized.
- Inverse-variance weighted (IVW) and sensitivity analyses (MR-Egger, weighted median) were performed to assess adiposity indicators.
Main Results:
- Significant correlations were found between adiposity indicators and facial aging.
- Strong evidence supports a causal link, with odds ratios (OR) indicating increased risk.
- Sensitivity analyses confirmed the robustness of the findings, addressing potential biases.
Conclusions:
- Mendelian randomization confirmed a statistically significant causal relationship between adiposity and facial aging.
- This study provides robust evidence for a causal link, moving beyond observational correlations.
- The findings have implications for understanding the interplay between metabolic health and appearance in aging populations.
Related Concept Videos
01:24Facial Feedback Hypothesis
186
Charles Darwin proposed that facial expressions are an evolutionary adaptation for communication. He argued that these expressions are not influenced by culture but are universal across species. For example, a snarling expression with exposed teeth signals a threat in many animals, including humans. Darwin also suggested that displaying an emotion can intensify the feeling. Smiling, for example, could enhance one's sense of happiness. This idea laid the foundation for understanding the role...
186
01:24Obesity
534
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
534
01:02Hypodermis
4.6K
The hypodermis (the subcutaneous layer or superficial fascia) is present directly below the dermis. It connects the skin to the underlying fascia (fibrous tissue) of the bones and muscles. It is not strictly a part of the skin, although the border between the hypodermis and dermis can be difficult to distinguish. The hypodermis consists of well-vascularized, loose, areolar connective tissue and adipose tissue, which functions as a mode of fat storage and provides insulation and cushioning for...
4.6K
02:12Relationship Formation
40.1K
What do you think is the single most influential factor in determining with whom you become friends and whom you form romantic relationships? You might be surprised to learn that the answer is simple: the people with whom you have the most contact. This most important factor is proximity. You are more likely to be friends with people you have regular contact with. For example, there are decades of research that shows that you are more likely to become friends with people who live in your dorm,...
40.1K
01:52Regression Toward the Mean
6.3K
Regression toward the mean (“RTM”) is a phenomenon in which extremely high or low values—for example, and individual’s blood pressure at a particular moment—appear closer to a group’s average upon remeasuring. Although this statistical peculiarity is the result of random error and chance, it has been problematic across various medical, scientific, financial and psychological applications. In particular, RTM, if not taken into account, can interfere when...
6.3K
01:17Two-Way ANOVA
2.7K
The two-way ANOVA is an extension of the one-way ANOVA. It is a statistical test performed on three or more samples categorized by two factors - a row factor and a column factor. Ronald Fischer mentioned it in 1925 in his book 'Statistical Methods for Researchers.'
The two-way ANOVA analysis initially begins by stating the null hypothesis that there is an interaction effect between the two factors of a dataset. This effect can be visualized using line segments formed by joining the...
The two-way ANOVA analysis initially begins by stating the null hypothesis that there is an interaction effect between the two factors of a dataset. This effect can be visualized using line segments formed by joining the...
2.7K