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MiRNA a New Insight in Metabolic and Human Diseases: A Review
1Department of Biotechnology, College of Sciences, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia. i.jafri@tu.edu.sa.
Abstract:
The purpose of this research is to examine existing studies on the association between microRNAs (miRNA) and age-related disorders. The miRNAs are small, noncoding RNA molecules with the ability to regulate gene expression. These are well-established in extracellular circulation, including various types of diseases such as cancer, cardiovascular diseases, and diabetes. Similarly, several miRNAs are associated with certain age-related conditions, such as increased miR-21 expression in cancer patients. Besides that, the miR-122 in atherosclerosis patients played an essential role in gene expression and disease. Therefore, the miRNA has the potential to serve as a reliable biomarker for the early detection, monitoring of progression, and regression of age-related diseases. To have a complete understanding of the mechanisms and the direct long-term effects that the miRNA has on the pathophysiology and development of diseases, additional research is required.
Insights
MicroRNAs (miRNAs) show promise as biomarkers for age-related diseases. Further research is needed to fully understand their role in disease development and progression.
Area of Science:
- Biochemistry
- Molecular Biology
- Genetics
Background:
- MicroRNAs (miRNAs) are small, noncoding RNA molecules that regulate gene expression.
- miRNAs are found in extracellular circulation and are implicated in various diseases, including cancer, cardiovascular disease, and diabetes.
- Specific miRNAs, like miR-21 in cancer and miR-122 in atherosclerosis, are linked to age-related conditions.
Approach:
- This research reviews existing studies on the association between miRNAs and age-related disorders.
- The review focuses on the role of miRNAs in gene expression and disease pathophysiology.
- The potential of miRNAs as biomarkers for early detection and disease monitoring is examined.
Key Points:
- miRNAs play a crucial role in regulating gene expression.
- Several miRNAs are associated with specific age-related diseases.
- miRNAs have potential as reliable biomarkers for early detection, progression monitoring, and regression assessment of age-related diseases.
Conclusions:
- miRNAs are promising biomarkers for age-related diseases.
- Additional research is required to fully elucidate the mechanisms and long-term effects of miRNAs in disease.
- Understanding miRNA functions is key to developing new diagnostic and therapeutic strategies for age-related conditions.
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