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The Interplay Between Blood Inflammatory Markers, Symptom Domains, and Severity of ADHD Disorder in Children

Afaf Mohammed Abdel Samei1, Dalia Abdel Moneim Mahmoud1, Beshoy Salem Boshra2

  • 1Ain Shams University, Cairo, Egypt.

Journal of Attention Disorders
|September 16, 2023
PubMed

Insights

Children with Attention-Deficit/Hyperactivity Disorder (ADHD) show elevated blood inflammatory markers, including neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR). However, these markers do not predict ADHD symptom severity or specific domains.

Area of Science:

  • Neuroscience
  • Immunology
  • Pediatrics

Background:

  • Attention-Deficit/Hyperactivity Disorder (ADHD) is a complex neurodevelopmental disorder with a multifactorial etiology.
  • The role of inflammation in ADHD pathogenesis is an emerging area of research.

Purpose of the Study:

  • To investigate the association between specific blood inflammatory markers and ADHD in children.
  • To explore the relationship between neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), mean platelet volume (MPV), ADHD symptom domains, and severity.

Main Methods:

  • A case-control study involving 50 children diagnosed with ADHD and 50 healthy controls.
  • Participants were assessed using standardized diagnostic and intelligence scales (MINI-KID, Wechsler Intelligence Scale for Children, Conners' Parent Rating Scale).
  • Blood samples were analyzed for NLR, PLR, and MPV.

Main Results:

  • Children with ADHD exhibited significantly higher levels of blood inflammatory markers compared to controls, excluding platelet count.
  • No significant correlation was found between NLR, PLR, or MPV and the subtypes or severity of ADHD symptoms.

Conclusions:

  • Blood inflammatory markers are elevated in children with ADHD, suggesting a potential inflammatory component.
  • Current inflammatory markers (NLR, PLR, MPV) do not serve as predictors for ADHD symptom domains or severity.
Abstract

Keywords:
ADHDMPVNLRPLRinflammatory markers

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