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Exploring core symptoms and interrelationships among symptoms in children with acute leukemia during chemotherapy: A

Jia Fang1, Li-Ling Xu2, Chun-Qin Liu3

  • 1Department of Nursing, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangdong Provincial Clinical Research Center for Child Health, Guangzhou, China.

Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer
|September 16, 2023
PubMed

Insights

Worrying and irritability are key symptoms in children with acute leukemia undergoing chemotherapy. Emotional symptoms, especially in older children and during induction/remission phases, require attention.

Area of Science:

  • Pediatric Oncology
  • Symptom Management
  • Psychosocial Oncology

Background:

  • Children with acute leukemia experience significant symptom burden during chemotherapy.
  • Limited research exists on the interconnectedness of these symptoms in pediatric acute leukemia.

Purpose of the Study:

  • To identify core symptoms experienced by children with acute leukemia during chemotherapy.
  • To elucidate the interrelationships among these symptoms using network analysis.

Main Methods:

  • A network analysis was conducted on data from 469 children with acute leukemia.
  • The Memorial Symptom Assessment Scale 10-18 (MSAS 10-18) was used to assess symptom prevalence and severity.
  • Centrality indices and network density were employed to analyze symptom interrelationships.

Main Results:

  • Worrying and irritability were identified as central symptoms based on strength, closeness, and betweenness.
  • Lack of energy was the most prevalent but less central symptom.
  • Symptom network density differed significantly during induction and remission phases compared to other cycles.

Conclusions:

  • Network analysis is a valuable tool for understanding symptom clusters in pediatric acute leukemia.
  • Emotional symptoms, particularly during induction/remission and in older children, warrant focused assessment.
  • Further longitudinal research is needed to explore dynamic symptom networks and causal relationships.
Abstract

Keywords:
Acute LeukemiaChildrenNetwork AnalysisNursing CareSymptoms Management

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